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Androgen regulation of rat renal angiotensinogen messenger RNA expression.

Publication ,  Journal Article
Ellison, KE; Ingelfinger, JR; Pivor, M; Dzau, VJ
Published in: J Clin Invest
June 1989

Renal angiotensinogen (ang-n) mRNA concentration in the male WKY rat increases significantly during puberty. Furthermore, renal angiotensinogen mRNA level in the adult female WKY rat is considerably lower than in the male. The present study investigates the role of androgen in differential renal ang-n mRNA expression. Northern and slot blot analyses with alpha-32P labeled ang-n cDNA (pRang 3) demonstrated that castration lowered ang-n mRNA levels in the male kidney by greater than or equal to 60% compared with control, suggesting that androgen may be involved with renal ang-n gene regulation. Moreover, male WKY rats castrated as weanlings and normal adult female WKY rats each implanted with testosterone displayed significant (P less than 0.05) increases in renal ang-n mRNA levels. Our observations, taken together with previous reports that androgen influences proximal tubule morphology and the tubular expression of transport proteins (e.g., Na+/H+ antiporter), may have important physiological implications for understanding the relationship between androgen and angiotensin in the regulation of tubular function.

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Published In

J Clin Invest

DOI

ISSN

0021-9738

Publication Date

June 1989

Volume

83

Issue

6

Start / End Page

1941 / 1945

Location

United States

Related Subject Headings

  • Testosterone
  • Sex Characteristics
  • Rats, Inbred WKY
  • Rats
  • RNA, Messenger
  • Orchiectomy
  • Nucleic Acid Hybridization
  • Male
  • Kidney
  • Immunology
 

Citation

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Ellison, K. E., Ingelfinger, J. R., Pivor, M., & Dzau, V. J. (1989). Androgen regulation of rat renal angiotensinogen messenger RNA expression. J Clin Invest, 83(6), 1941–1945. https://doi.org/10.1172/JCI114102
Ellison, K. E., J. R. Ingelfinger, M. Pivor, and V. J. Dzau. “Androgen regulation of rat renal angiotensinogen messenger RNA expression.J Clin Invest 83, no. 6 (June 1989): 1941–45. https://doi.org/10.1172/JCI114102.
Ellison KE, Ingelfinger JR, Pivor M, Dzau VJ. Androgen regulation of rat renal angiotensinogen messenger RNA expression. J Clin Invest. 1989 Jun;83(6):1941–5.
Ellison, K. E., et al. “Androgen regulation of rat renal angiotensinogen messenger RNA expression.J Clin Invest, vol. 83, no. 6, June 1989, pp. 1941–45. Pubmed, doi:10.1172/JCI114102.
Ellison KE, Ingelfinger JR, Pivor M, Dzau VJ. Androgen regulation of rat renal angiotensinogen messenger RNA expression. J Clin Invest. 1989 Jun;83(6):1941–1945.

Published In

J Clin Invest

DOI

ISSN

0021-9738

Publication Date

June 1989

Volume

83

Issue

6

Start / End Page

1941 / 1945

Location

United States

Related Subject Headings

  • Testosterone
  • Sex Characteristics
  • Rats, Inbred WKY
  • Rats
  • RNA, Messenger
  • Orchiectomy
  • Nucleic Acid Hybridization
  • Male
  • Kidney
  • Immunology