Skip to main content

Possible prorenin activating mechanisms in the blood vessel wall.

Publication ,  Journal Article
Dzau, VJ
Published in: J Hypertens Suppl
July 1987

The blood-vessel wall has the potential for activating circulating prorenin by several mechanisms. Prorenin may be taken up by the blood vessel and activated by enzyme(s) localized on the vascular cells. We do not know whether this mechanism is usually operative or is only activated under certain conditions. This local activation system can increase the vascular-wall renin concentration and may be involved with the regulation of local vascular tone and regional blood flow. Circulating blood cells may release enzymes which can activate prorenin. At the inflammatory site, a neutrophil-dependent prorenin activating mechanism may be important for the increased production of angiotensin II which modulates vascular permeability and tone. In addition, at sites of vascular injury where platelets aggregate, prorenin may be activated locally and may play a role in the genesis of vasospasm.

Duke Scholars

Published In

J Hypertens Suppl

DOI

ISSN

0952-1178

Publication Date

July 1987

Volume

5

Issue

2

Start / End Page

S15 / S18

Location

England

Related Subject Headings

  • Renin-Angiotensin System
  • Renin
  • Neutrophils
  • Humans
  • Enzyme Precursors
  • Enzyme Activation
  • Endothelium
  • Cardiovascular System & Hematology
  • Blood Vessels
  • Blood Platelets
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Dzau, V. J. (1987). Possible prorenin activating mechanisms in the blood vessel wall. J Hypertens Suppl, 5(2), S15–S18. https://doi.org/10.1097/00004872-198707002-00004
Dzau, V. J. “Possible prorenin activating mechanisms in the blood vessel wall.J Hypertens Suppl 5, no. 2 (July 1987): S15–18. https://doi.org/10.1097/00004872-198707002-00004.
Dzau VJ. Possible prorenin activating mechanisms in the blood vessel wall. J Hypertens Suppl. 1987 Jul;5(2):S15–8.
Dzau, V. J. “Possible prorenin activating mechanisms in the blood vessel wall.J Hypertens Suppl, vol. 5, no. 2, July 1987, pp. S15–18. Pubmed, doi:10.1097/00004872-198707002-00004.
Dzau VJ. Possible prorenin activating mechanisms in the blood vessel wall. J Hypertens Suppl. 1987 Jul;5(2):S15–S18.

Published In

J Hypertens Suppl

DOI

ISSN

0952-1178

Publication Date

July 1987

Volume

5

Issue

2

Start / End Page

S15 / S18

Location

England

Related Subject Headings

  • Renin-Angiotensin System
  • Renin
  • Neutrophils
  • Humans
  • Enzyme Precursors
  • Enzyme Activation
  • Endothelium
  • Cardiovascular System & Hematology
  • Blood Vessels
  • Blood Platelets