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Vascular wall renin-angiotensin pathway in control of the circulation. A hypothesis.

Publication ,  Journal Article
Dzau, VJ
Published in: Am J Med
October 5, 1984

Multiple lines of evidence support the existence of a vascular renin-angiotensin system independent of the circulating system. Vascular renin appears to originate from both uptake of plasma renin and in situ synthesis. Renin may bind to vascular endothelium. In addition, the endothelium is capable of activating inactive renin. Cell-surface-bound renin and angiotensin-converting enzyme constitute a biochemical cascade on the endothelial surface, resulting in a high local concentration of angiotensin. The role of the intracellular system is unclear. Intracellular angiotensin may regulate the angiotensin receptor and modulate the vascular response to exogenous angiotensins. Recent data also suggest that neutrophils and platelets provide mobile pathways by which cell-bound or released enzymes can activate and amplify the renin-angiotensin biochemical cascade. The mobile angiotensin pathways may be important in the inflammatory vascular response, edema formation, and vasospasm of vascular injury. Taken together, the vascular wall renin-angiotensin system may play an important role in cardiovascular homeostasis. We postulate that abnormalities in the control of this system may result in local vasospasm or systemic hypertension.

Duke Scholars

Published In

Am J Med

DOI

ISSN

0002-9343

Publication Date

October 5, 1984

Volume

77

Issue

4A

Start / End Page

31 / 36

Location

United States

Related Subject Headings

  • Renin-Angiotensin System
  • Renin
  • Neutrophils
  • Muscle, Smooth, Vascular
  • Humans
  • Homeostasis
  • General & Internal Medicine
  • Fluorescent Antibody Technique
  • Endothelium
  • Blood Platelets
 

Citation

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ICMJE
MLA
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Dzau, V. J. (1984). Vascular wall renin-angiotensin pathway in control of the circulation. A hypothesis. Am J Med, 77(4A), 31–36. https://doi.org/10.1016/s0002-9343(84)80035-2
Dzau, V. J. “Vascular wall renin-angiotensin pathway in control of the circulation. A hypothesis.Am J Med 77, no. 4A (October 5, 1984): 31–36. https://doi.org/10.1016/s0002-9343(84)80035-2.
Dzau, V. J. “Vascular wall renin-angiotensin pathway in control of the circulation. A hypothesis.Am J Med, vol. 77, no. 4A, Oct. 1984, pp. 31–36. Pubmed, doi:10.1016/s0002-9343(84)80035-2.
Journal cover image

Published In

Am J Med

DOI

ISSN

0002-9343

Publication Date

October 5, 1984

Volume

77

Issue

4A

Start / End Page

31 / 36

Location

United States

Related Subject Headings

  • Renin-Angiotensin System
  • Renin
  • Neutrophils
  • Muscle, Smooth, Vascular
  • Humans
  • Homeostasis
  • General & Internal Medicine
  • Fluorescent Antibody Technique
  • Endothelium
  • Blood Platelets