Skip to main content

Renal response to captopril in severe heart failure: role of furosemide in natriuresis and reversal of hyponatremia.

Publication ,  Journal Article
Dzau, VJ; Hollenberg, NK
Published in: Ann Intern Med
June 1984

To assess the effect of furosemide and captopril on renal function and hyponatremia in patients with severe heart failure, we studied two groups of patients with hyponatremia who were receiving digoxin therapy and whose sodium intake was 40 meq/d. One group received captopril and furosemide, the second received captopril. The first group responded to combination therapy with a brisk natriuresis and diuresis, weight reduction, and an increase in serum sodium concentration. Patients who received captopril alone did not respond, despite a similar increase in renal plasma flow and glomerular filtration rate. When furosemide was then administered to patients who had received captopril alone, a brisk natriuresis, weight loss, and correction of hyponatremia followed. Treatment with furosemide is necessary to promote natriuresis and correction of hyponatremia in patients with severe heart failure treated with captopril; the renal vascular action of captopril enhances the effectiveness of furosemide.

Duke Scholars

Published In

Ann Intern Med

DOI

ISSN

0003-4819

Publication Date

June 1984

Volume

100

Issue

6

Start / End Page

777 / 782

Location

United States

Related Subject Headings

  • Renal Circulation
  • Proline
  • Potassium
  • Natriuresis
  • Middle Aged
  • Male
  • Kidney
  • Hyponatremia
  • Humans
  • Heart Failure
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Dzau, V. J., & Hollenberg, N. K. (1984). Renal response to captopril in severe heart failure: role of furosemide in natriuresis and reversal of hyponatremia. Ann Intern Med, 100(6), 777–782. https://doi.org/10.7326/0003-4819-100-6-777
Dzau, V. J., and N. K. Hollenberg. “Renal response to captopril in severe heart failure: role of furosemide in natriuresis and reversal of hyponatremia.Ann Intern Med 100, no. 6 (June 1984): 777–82. https://doi.org/10.7326/0003-4819-100-6-777.
Dzau, V. J., and N. K. Hollenberg. “Renal response to captopril in severe heart failure: role of furosemide in natriuresis and reversal of hyponatremia.Ann Intern Med, vol. 100, no. 6, June 1984, pp. 777–82. Pubmed, doi:10.7326/0003-4819-100-6-777.

Published In

Ann Intern Med

DOI

ISSN

0003-4819

Publication Date

June 1984

Volume

100

Issue

6

Start / End Page

777 / 782

Location

United States

Related Subject Headings

  • Renal Circulation
  • Proline
  • Potassium
  • Natriuresis
  • Middle Aged
  • Male
  • Kidney
  • Hyponatremia
  • Humans
  • Heart Failure