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Vascular renin-angiotensin: a possible autocrine or paracrine system in control of vascular function.

Publication ,  Journal Article
Dzau, VJ
Published in: J Cardiovasc Pharmacol
1984

Circulating angiotensin influences vascular tone via its receptors particularly at the precapillary vessels. In addition, an intrinsic renin-angiotensin system has been postulated to exist in vascular wall. In this study, we documented components of the renin-angiotensin system in cultured vascular smooth-muscle cells. These cells are capable of angiotensin formation. Approximately 50% of the angiotensin-generating activity is neutralized by a renin-specific antibody. Immunoaffinity-purified vascular renin has a pH optimum of 6.8 and a molecular weight of 38,000. The intracellular renin concentration increases fourfold when cultured in serum-free media for 48 h, suggesting physiological regulation by serum factor(s). Cultured vascular smooth-muscle cells also contain angiotensinogen and immunoreactive angiotensins. We postulate that these elements constitute an intrinsic system that exerts an autocrine or paracrine influence on local vascular function, including vascular tone.

Duke Scholars

Published In

J Cardiovasc Pharmacol

ISSN

0160-2446

Publication Date

1984

Volume

6 Suppl 2

Start / End Page

S377 / S382

Location

United States

Related Subject Headings

  • Renin-Angiotensin System
  • Renin
  • Muscle, Smooth, Vascular
  • Kinetics
  • Hydrogen-Ion Concentration
  • Dogs
  • Cells, Cultured
  • Cardiovascular System & Hematology
  • Animals
  • Angiotensinogen
 

Citation

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MLA
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Dzau, V. J. (1984). Vascular renin-angiotensin: a possible autocrine or paracrine system in control of vascular function. J Cardiovasc Pharmacol, 6 Suppl 2, S377–S382.
Dzau, V. J. “Vascular renin-angiotensin: a possible autocrine or paracrine system in control of vascular function.J Cardiovasc Pharmacol 6 Suppl 2 (1984): S377–82.
Dzau, V. J. “Vascular renin-angiotensin: a possible autocrine or paracrine system in control of vascular function.J Cardiovasc Pharmacol, vol. 6 Suppl 2, 1984, pp. S377–82.

Published In

J Cardiovasc Pharmacol

ISSN

0160-2446

Publication Date

1984

Volume

6 Suppl 2

Start / End Page

S377 / S382

Location

United States

Related Subject Headings

  • Renin-Angiotensin System
  • Renin
  • Muscle, Smooth, Vascular
  • Kinetics
  • Hydrogen-Ion Concentration
  • Dogs
  • Cells, Cultured
  • Cardiovascular System & Hematology
  • Animals
  • Angiotensinogen