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Subcutaneous administration of nimodipine improves bioavailability in rabbits.

Publication ,  Journal Article
Laslo, AM; Eastwood, JD; Urquhart, B; Lee, T-Y; Freeman, D
Published in: J Neurosci Methods
October 30, 2004

We compared subcutaneous and oral methods of nimodipine administration to determine a method of nimodipine administration that maintained serum levels at or above the optimal therapeutic concentration (7 ng/ml). Plasma concentrations of nimodipine were measured in New Zealand White rabbits (2.6-3.9 kg). First, peak plasma concentration (C(max)), time to reach peak plasma concentration (T(max)), and area under the curve (AUC) parameters were calculated and compared between animals receiving oral or subcutaneous nimodipine (5-15 mg/kg). Next, plasma concentrations were measured 24 h after subcutaneous administration of 2.5 mg/kg of nimodipine in healthy animals and animals with experimentally induced SAH. C(max), T(max) and AUC parameters were significantly greater for subcutaneous compared to oral nimodipine administration, irrespective of dose. Mean nimodipine concentrations at 24 h were >7 ng/ml in both healthy animals (12.9 +/- 10.0 ng/ml) and in animals with SAH (11.8 +/- 4.6 ng/ml) that received 2.5 mg/kg of subcutaneous nimodipine. In this model, the subcutaneous method of nimodipine administration consistently maintains plasma levels at or above the optimal therapeutic concentration, whereas oral administration fails to do so.

Duke Scholars

Published In

J Neurosci Methods

DOI

ISSN

0165-0270

Publication Date

October 30, 2004

Volume

139

Issue

2

Start / End Page

195 / 201

Location

Netherlands

Related Subject Headings

  • Rabbits
  • Nimodipine
  • Neurology & Neurosurgery
  • Male
  • Injections, Subcutaneous
  • Dose-Response Relationship, Drug
  • Biological Availability
  • Animals
  • 1702 Cognitive Sciences
  • 1701 Psychology
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Laslo, A. M., Eastwood, J. D., Urquhart, B., Lee, T.-Y., & Freeman, D. (2004). Subcutaneous administration of nimodipine improves bioavailability in rabbits. J Neurosci Methods, 139(2), 195–201. https://doi.org/10.1016/j.jneumeth.2004.04.030
Laslo, Amanda M., James D. Eastwood, Brad Urquhart, Ting-Yim Lee, and Dave Freeman. “Subcutaneous administration of nimodipine improves bioavailability in rabbits.J Neurosci Methods 139, no. 2 (October 30, 2004): 195–201. https://doi.org/10.1016/j.jneumeth.2004.04.030.
Laslo AM, Eastwood JD, Urquhart B, Lee T-Y, Freeman D. Subcutaneous administration of nimodipine improves bioavailability in rabbits. J Neurosci Methods. 2004 Oct 30;139(2):195–201.
Laslo, Amanda M., et al. “Subcutaneous administration of nimodipine improves bioavailability in rabbits.J Neurosci Methods, vol. 139, no. 2, Oct. 2004, pp. 195–201. Pubmed, doi:10.1016/j.jneumeth.2004.04.030.
Laslo AM, Eastwood JD, Urquhart B, Lee T-Y, Freeman D. Subcutaneous administration of nimodipine improves bioavailability in rabbits. J Neurosci Methods. 2004 Oct 30;139(2):195–201.
Journal cover image

Published In

J Neurosci Methods

DOI

ISSN

0165-0270

Publication Date

October 30, 2004

Volume

139

Issue

2

Start / End Page

195 / 201

Location

Netherlands

Related Subject Headings

  • Rabbits
  • Nimodipine
  • Neurology & Neurosurgery
  • Male
  • Injections, Subcutaneous
  • Dose-Response Relationship, Drug
  • Biological Availability
  • Animals
  • 1702 Cognitive Sciences
  • 1701 Psychology