Tempostatin™ (halofuginone) inhibits collagen deposition in fibrous capsules
Publication
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Olbrich, KC; Meade, RA; Bruno, W; Sundin, BM; Heller, L; Erdmann, D; Levin, LS; Klitzman, B
Published in: Transactions - 7th World Biomaterials Congress
December 1, 2004
A study proposed to see the effectiveness of a collagen type I synthesis inhibitor, Tempostatin™ (Halofuginone), at inhibiting collagen deposition around implanted materials was discussed. The data indicated that halofuginone was effective at inhibiting the deposition of collagen within the capsule that formed around the implanted silicone. It was also indicated that halofuginone inhibited collagen synthesis by inhibiting TGF-β activity. The presence of TGF-beta in the peri-implant space suggested that halofuginone treatment may be an effective method for minimizing fibrous capsule formation around implants.
Duke Scholars
Published In
Transactions - 7th World Biomaterials Congress
Publication Date
December 1, 2004
Start / End Page
294
Citation
APA
Chicago
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MLA
NLM
Olbrich, K. C., Meade, R. A., Bruno, W., Sundin, B. M., Heller, L., Erdmann, D., … Klitzman, B. (2004). Tempostatin™ (halofuginone) inhibits collagen deposition in fibrous capsules. Transactions - 7th World Biomaterials Congress.
Olbrich, K. C., R. A. Meade, W. Bruno, B. M. Sundin, L. Heller, D. Erdmann, L. S. Levin, and B. Klitzman. “Tempostatin™ (halofuginone) inhibits collagen deposition in fibrous capsules.” Transactions - 7th World Biomaterials Congress, December 1, 2004.
Olbrich KC, Meade RA, Bruno W, Sundin BM, Heller L, Erdmann D, et al. Tempostatin™ (halofuginone) inhibits collagen deposition in fibrous capsules. Transactions - 7th World Biomaterials Congress. 2004. p. 294.
Olbrich, K. C., et al. “Tempostatin™ (halofuginone) inhibits collagen deposition in fibrous capsules.” Transactions - 7th World Biomaterials Congress, 1 Dec. 2004, p. 294.
Olbrich KC, Meade RA, Bruno W, Sundin BM, Heller L, Erdmann D, Levin LS, Klitzman B. Tempostatin™ (halofuginone) inhibits collagen deposition in fibrous capsules. Transactions - 7th World Biomaterials Congress. 2004. p. 294.
Published In
Transactions - 7th World Biomaterials Congress
Publication Date
December 1, 2004
Start / End Page
294