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Lack of infection in HIV-exposed individuals is associated with a strong CD8(+) cell noncytotoxic anti-HIV response.

Publication ,  Journal Article
Stranford, SA; Skurnick, J; Louria, D; Osmond, D; Chang, SY; Sninsky, J; Ferrari, G; Weinhold, K; Lindquist, C; Levy, JA
Published in: Proc Natl Acad Sci U S A
February 2, 1999

Individuals repeatedly exposed to HIV, but who remain uninfected, form a population enriched for persons likely to have either natural or acquired resistance to the virus. We have studied four such exposed uninfected cohorts, representing 60 individuals, for evidence of protective immunity. This population included participants exposed to HIV through anal or vaginal receptive intercourse on multiple occasions over many years. We observed CD8(+)-cell noncytotoxic inhibition of HIV replication in acutely infected CD4(+) cells in the vast majority of individuals most recently exposed to the virus (within 1 year). The levels of this CD8(+)-cell response were sufficient to inhibit the in vitro infection of the exposed subjects' peripheral blood mononuclear cells. We found no evidence of a significant role for CCR5 Delta32 mutation in this population, nor did CD4(+) cell susceptibility to infection or HIV-specific cytotoxic T-lymphocytes correlate with resistance to infection in the individuals tested. Therefore, the observed strong noncytotoxic CD8(+)-cell anti-HIV responses may be an antiviral immune activity contributing to the apparent protection from infection in these exposed uninfected individuals.

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Published In

Proc Natl Acad Sci U S A

DOI

ISSN

0027-8424

Publication Date

February 2, 1999

Volume

96

Issue

3

Start / End Page

1030 / 1035

Location

United States

Related Subject Headings

  • Virus Replication
  • T-Lymphocyte Subsets
  • Sexual Behavior
  • Risk Factors
  • Receptors, CCR5
  • Middle Aged
  • Male
  • Immunity, Innate
  • Humans
  • HIV-1
 

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Stranford, S. A., Skurnick, J., Louria, D., Osmond, D., Chang, S. Y., Sninsky, J., … Levy, J. A. (1999). Lack of infection in HIV-exposed individuals is associated with a strong CD8(+) cell noncytotoxic anti-HIV response. Proc Natl Acad Sci U S A, 96(3), 1030–1035. https://doi.org/10.1073/pnas.96.3.1030
Stranford, S. A., J. Skurnick, D. Louria, D. Osmond, S. Y. Chang, J. Sninsky, G. Ferrari, K. Weinhold, C. Lindquist, and J. A. Levy. “Lack of infection in HIV-exposed individuals is associated with a strong CD8(+) cell noncytotoxic anti-HIV response.Proc Natl Acad Sci U S A 96, no. 3 (February 2, 1999): 1030–35. https://doi.org/10.1073/pnas.96.3.1030.
Stranford SA, Skurnick J, Louria D, Osmond D, Chang SY, Sninsky J, et al. Lack of infection in HIV-exposed individuals is associated with a strong CD8(+) cell noncytotoxic anti-HIV response. Proc Natl Acad Sci U S A. 1999 Feb 2;96(3):1030–5.
Stranford, S. A., et al. “Lack of infection in HIV-exposed individuals is associated with a strong CD8(+) cell noncytotoxic anti-HIV response.Proc Natl Acad Sci U S A, vol. 96, no. 3, Feb. 1999, pp. 1030–35. Pubmed, doi:10.1073/pnas.96.3.1030.
Stranford SA, Skurnick J, Louria D, Osmond D, Chang SY, Sninsky J, Ferrari G, Weinhold K, Lindquist C, Levy JA. Lack of infection in HIV-exposed individuals is associated with a strong CD8(+) cell noncytotoxic anti-HIV response. Proc Natl Acad Sci U S A. 1999 Feb 2;96(3):1030–1035.
Journal cover image

Published In

Proc Natl Acad Sci U S A

DOI

ISSN

0027-8424

Publication Date

February 2, 1999

Volume

96

Issue

3

Start / End Page

1030 / 1035

Location

United States

Related Subject Headings

  • Virus Replication
  • T-Lymphocyte Subsets
  • Sexual Behavior
  • Risk Factors
  • Receptors, CCR5
  • Middle Aged
  • Male
  • Immunity, Innate
  • Humans
  • HIV-1