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The genomic relationship between primary breast carcinomas and their nodal metastases.

Publication ,  Journal Article
Desouki, MM; Liao, S; Conroy, J; Nowak, NJ; Shepherd, L; Gaile, DP; Geradts, J
Published in: Cancer Invest
May 2011

We screened the whole tumor genome to identify DNA copy number gains and losses that discriminate between primary breast carcinomas (MP) and their nodal metastases (ML). Six candidate genes were confirmed by quantitative PCR to have differentially distributed copy number changes. Three of the genes (ERRγ, DDX6, and TIAM1) were more commonly amplified in nodal metastases. Principal component analysis revealed that MP-ML pairs varied markedly in their genomic divergence. The latter was larger in PR-negative tumors. Nodal metastases may form early or late in the development of breast carcinomas and PR-negative tumors may metastasize earlier or are genomically less stable.

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Published In

Cancer Invest

DOI

EISSN

1532-4192

Publication Date

May 2011

Volume

29

Issue

4

Start / End Page

300 / 307

Location

England

Related Subject Headings

  • Principal Component Analysis
  • Polymerase Chain Reaction
  • Oncology & Carcinogenesis
  • Lymphatic Metastasis
  • Humans
  • Genetic Association Studies
  • Gene Expression Regulation, Neoplastic
  • Gene Expression Profiling
  • Female
  • DNA Copy Number Variations
 

Citation

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Desouki, M. M., Liao, S., Conroy, J., Nowak, N. J., Shepherd, L., Gaile, D. P., & Geradts, J. (2011). The genomic relationship between primary breast carcinomas and their nodal metastases. Cancer Invest, 29(4), 300–307. https://doi.org/10.3109/07357907.2011.568564
Desouki, Mohamed M., Shaoxi Liao, Jeffrey Conroy, Norma J. Nowak, Lori Shepherd, Daniel P. Gaile, and Joseph Geradts. “The genomic relationship between primary breast carcinomas and their nodal metastases.Cancer Invest 29, no. 4 (May 2011): 300–307. https://doi.org/10.3109/07357907.2011.568564.
Desouki MM, Liao S, Conroy J, Nowak NJ, Shepherd L, Gaile DP, et al. The genomic relationship between primary breast carcinomas and their nodal metastases. Cancer Invest. 2011 May;29(4):300–7.
Desouki, Mohamed M., et al. “The genomic relationship between primary breast carcinomas and their nodal metastases.Cancer Invest, vol. 29, no. 4, May 2011, pp. 300–07. Pubmed, doi:10.3109/07357907.2011.568564.
Desouki MM, Liao S, Conroy J, Nowak NJ, Shepherd L, Gaile DP, Geradts J. The genomic relationship between primary breast carcinomas and their nodal metastases. Cancer Invest. 2011 May;29(4):300–307.

Published In

Cancer Invest

DOI

EISSN

1532-4192

Publication Date

May 2011

Volume

29

Issue

4

Start / End Page

300 / 307

Location

England

Related Subject Headings

  • Principal Component Analysis
  • Polymerase Chain Reaction
  • Oncology & Carcinogenesis
  • Lymphatic Metastasis
  • Humans
  • Genetic Association Studies
  • Gene Expression Regulation, Neoplastic
  • Gene Expression Profiling
  • Female
  • DNA Copy Number Variations