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Dextromethorphan alters cerebral blood flow and protects against cerebral injury following focal ischemia.

Publication ,  Journal Article
Steinberg, GK; Lo, EH; Kunis, DM; Grant, GA; Poljak, A; DeLaPaz, R
Published in: Neurosci Lett
December 9, 1991

The effects of the N-methyl-D-aspartate (NMDA) antagonist dextromethorphan (DM) on regional cerebral blood flow (rCBF) and cerebral injury were studied in a rabbit model of transient focal ischemia. Anesthetized rabbits underwent 2 h occlusion of the left internal carotid, middle cerebral and anterior cerebral artery, followed by 4 h of reperfusion. Ten minutes after the onset of ischemia they were treated with either i.v. DM 20 mg/kg followed by 10 mg/kg/h (n = 6) or normal saline (NS, n = 5). Control rabbits received DM (n = 3) or NS (n = 2) infusion without arterial occlusion. DM attenuated the sharp, post-ischemic rise in rCBF seen during reperfusion within the ischemic core of NS controls (DM 31% pre-ischemic value, NS 92%). DM also improved the delayed post-ischemic hypoperfusion compared with controls. DM infusion without arterial occlusion did not change rCBF values. Compared with NS controls, DM treated animals demonstrated recovery of the somatosensory evoked potential (DM 96% pre-ischemic values, NS 24%), 76% reduction in cortical edema and 92% decrease in cortical ischemic neuronal damage. We conclude that DM's effect on CBF may contribute to its neuroprotective action.

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Published In

Neurosci Lett

DOI

ISSN

0304-3940

Publication Date

December 9, 1991

Volume

133

Issue

2

Start / End Page

225 / 228

Location

Ireland

Related Subject Headings

  • Reperfusion
  • Rabbits
  • Neurons
  • Male
  • Magnetic Resonance Imaging
  • Ischemic Attack, Transient
  • Evoked Potentials, Somatosensory
  • Electric Stimulation
  • Dextromethorphan
  • Cerebrovascular Circulation
 

Citation

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Steinberg, G. K., Lo, E. H., Kunis, D. M., Grant, G. A., Poljak, A., & DeLaPaz, R. (1991). Dextromethorphan alters cerebral blood flow and protects against cerebral injury following focal ischemia. Neurosci Lett, 133(2), 225–228. https://doi.org/10.1016/0304-3940(91)90575-e
Steinberg, G. K., E. H. Lo, D. M. Kunis, G. A. Grant, A. Poljak, and R. DeLaPaz. “Dextromethorphan alters cerebral blood flow and protects against cerebral injury following focal ischemia.Neurosci Lett 133, no. 2 (December 9, 1991): 225–28. https://doi.org/10.1016/0304-3940(91)90575-e.
Steinberg GK, Lo EH, Kunis DM, Grant GA, Poljak A, DeLaPaz R. Dextromethorphan alters cerebral blood flow and protects against cerebral injury following focal ischemia. Neurosci Lett. 1991 Dec 9;133(2):225–8.
Steinberg, G. K., et al. “Dextromethorphan alters cerebral blood flow and protects against cerebral injury following focal ischemia.Neurosci Lett, vol. 133, no. 2, Dec. 1991, pp. 225–28. Pubmed, doi:10.1016/0304-3940(91)90575-e.
Steinberg GK, Lo EH, Kunis DM, Grant GA, Poljak A, DeLaPaz R. Dextromethorphan alters cerebral blood flow and protects against cerebral injury following focal ischemia. Neurosci Lett. 1991 Dec 9;133(2):225–228.
Journal cover image

Published In

Neurosci Lett

DOI

ISSN

0304-3940

Publication Date

December 9, 1991

Volume

133

Issue

2

Start / End Page

225 / 228

Location

Ireland

Related Subject Headings

  • Reperfusion
  • Rabbits
  • Neurons
  • Male
  • Magnetic Resonance Imaging
  • Ischemic Attack, Transient
  • Evoked Potentials, Somatosensory
  • Electric Stimulation
  • Dextromethorphan
  • Cerebrovascular Circulation