Skip to main content
Journal cover image

A high-resolution integrated physical, cytogenetic, and genetic map of human chromosome 11: distal p13 to proximal p15.1.

Publication ,  Journal Article
Fantes, JA; Oghene, K; Boyle, S; Danes, S; Fletcher, JM; Bruford, EA; Williamson, K; Seawright, A; Schedl, A; Hanson, I
Published in: Genomics
January 20, 1995

We describe a detailed physical map of human chromosome 11, extending from the distal part of p13 through the entirety of p14 to proximal p15.1. The primary level of mapping is based on chromosome breakpoints that divide the region into 20 intervals. At higher resolution YACs cover approximately 12 Mb of the region, and in many places overlapping cosmids are ordered in contiguous arrays. The map incorporates 18 known genes, including precise localization of the GTF2H1 gene encoding the 62-kDa subunit of TFIIH. We have also localized four expressed sequences of unknown function. The physical map incorporates genetic markers that allow relationships between physical and genetic distance to be examined, and similarly includes markers from a radiation hybrid map of 11. The cytogenetic location of cosmids has been examined on high-resolution banded chromosomes by fluorescence in situ hybridization, and FLpter values have been determined. The map therefore fully integrates physical, genic, genetic, and cytogenetic information and should provide a robust framework for the rapid and accurate assignment of new markers at a high level of resolution in this region of 11p.

Duke Scholars

Published In

Genomics

DOI

ISSN

0888-7543

Publication Date

January 20, 1995

Volume

25

Issue

2

Start / End Page

447 / 461

Location

United States

Related Subject Headings

  • Polymerase Chain Reaction
  • Molecular Sequence Data
  • In Situ Hybridization, Fluorescence
  • Humans
  • Genetics & Heredity
  • Genetic Markers
  • Genes, Wilms Tumor
  • Genes
  • Gene Expression
  • Electrophoresis, Gel, Pulsed-Field
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Fantes, J. A., Oghene, K., Boyle, S., Danes, S., Fletcher, J. M., Bruford, E. A., … Hanson, I. (1995). A high-resolution integrated physical, cytogenetic, and genetic map of human chromosome 11: distal p13 to proximal p15.1. Genomics, 25(2), 447–461. https://doi.org/10.1016/0888-7543(95)80045-n
Fantes, J. A., K. Oghene, S. Boyle, S. Danes, J. M. Fletcher, E. A. Bruford, K. Williamson, A. Seawright, A. Schedl, and I. Hanson. “A high-resolution integrated physical, cytogenetic, and genetic map of human chromosome 11: distal p13 to proximal p15.1.Genomics 25, no. 2 (January 20, 1995): 447–61. https://doi.org/10.1016/0888-7543(95)80045-n.
Fantes JA, Oghene K, Boyle S, Danes S, Fletcher JM, Bruford EA, et al. A high-resolution integrated physical, cytogenetic, and genetic map of human chromosome 11: distal p13 to proximal p15.1. Genomics. 1995 Jan 20;25(2):447–61.
Fantes, J. A., et al. “A high-resolution integrated physical, cytogenetic, and genetic map of human chromosome 11: distal p13 to proximal p15.1.Genomics, vol. 25, no. 2, Jan. 1995, pp. 447–61. Pubmed, doi:10.1016/0888-7543(95)80045-n.
Fantes JA, Oghene K, Boyle S, Danes S, Fletcher JM, Bruford EA, Williamson K, Seawright A, Schedl A, Hanson I. A high-resolution integrated physical, cytogenetic, and genetic map of human chromosome 11: distal p13 to proximal p15.1. Genomics. 1995 Jan 20;25(2):447–461.
Journal cover image

Published In

Genomics

DOI

ISSN

0888-7543

Publication Date

January 20, 1995

Volume

25

Issue

2

Start / End Page

447 / 461

Location

United States

Related Subject Headings

  • Polymerase Chain Reaction
  • Molecular Sequence Data
  • In Situ Hybridization, Fluorescence
  • Humans
  • Genetics & Heredity
  • Genetic Markers
  • Genes, Wilms Tumor
  • Genes
  • Gene Expression
  • Electrophoresis, Gel, Pulsed-Field