Effects of tissue electrical properties on neural excitation

The influence of anisotropy and inhomogeneity of tissue electrical conductivity on the relationship between the threshold current and the electrode-to-fiber distance was determined by computer simulation. Anisotropy affected both the slope and offset of the current-distance curve. Inhomogeneity also affected the slope and offset of the current-distance curves, and in some cases caused reversals in recruitment order. This study demonstrates the importance of accurate representation of tissue electrical properties when modeling extracellular electrical stimulation.

Duke Scholars

Author Warren M. Grill Biomedical Engineering