Guttiferone I, a new prenylated benzophenone from Garcinia humilis as a liver X receptor ligand.
Publication
, Journal Article
Herath, K; Jayasuriya, H; Ondeyka, JG; Guan, Z; Borris, RP; Stijfhoorn, E; Stevenson, D; Wang, J; Sharma, N; Macnaul, K; Menke, JG; Ali, A ...
Published in: J Nat Prod
April 2005
Liver X receptors (LXR) have been implicated in cholesterol homeostasis. Agonists of LXR are expected to increase cholesterol efflux, lower LDL, and raise HDL levels. Screening of a natural product library of plant extracts using a LXR-SPA binding assay and bioassay-guided fractionation of the bark and stem extract of Garcinia humilis led to the discovery of a new polyisoprenylated benzophenone named guttiferone I (1). The IC(50) value for this compound in the LXRalpha-SPA binding assay was 3.4 muM. Details of the isolation, structure elucidation, and ligand binding activity of 1 are described.
Duke Scholars
Published In
J Nat Prod
DOI
ISSN
0163-3864
Publication Date
April 2005
Volume
68
Issue
4
Start / End Page
617 / 619
Location
United States
Related Subject Headings
- Receptors, Cytoplasmic and Nuclear
- Orphan Nuclear Receptors
- Molecular Structure
- Medicinal & Biomolecular Chemistry
- Liver X Receptors
- Liver
- Ligands
- Inhibitory Concentration 50
- Garcinia
- DNA-Binding Proteins
Citation
APA
Chicago
ICMJE
MLA
NLM
Herath, K., Jayasuriya, H., Ondeyka, J. G., Guan, Z., Borris, R. P., Stijfhoorn, E., … Singh, S. B. (2005). Guttiferone I, a new prenylated benzophenone from Garcinia humilis as a liver X receptor ligand. J Nat Prod, 68(4), 617–619. https://doi.org/10.1021/np050045j
Herath, Kithsiri, Hiranthi Jayasuriya, John G. Ondeyka, Ziqiang Guan, Robert P. Borris, Eirik Stijfhoorn, Dennis Stevenson, et al. “Guttiferone I, a new prenylated benzophenone from Garcinia humilis as a liver X receptor ligand.” J Nat Prod 68, no. 4 (April 2005): 617–19. https://doi.org/10.1021/np050045j.
Herath K, Jayasuriya H, Ondeyka JG, Guan Z, Borris RP, Stijfhoorn E, et al. Guttiferone I, a new prenylated benzophenone from Garcinia humilis as a liver X receptor ligand. J Nat Prod. 2005 Apr;68(4):617–9.
Herath, Kithsiri, et al. “Guttiferone I, a new prenylated benzophenone from Garcinia humilis as a liver X receptor ligand.” J Nat Prod, vol. 68, no. 4, Apr. 2005, pp. 617–19. Pubmed, doi:10.1021/np050045j.
Herath K, Jayasuriya H, Ondeyka JG, Guan Z, Borris RP, Stijfhoorn E, Stevenson D, Wang J, Sharma N, Macnaul K, Menke JG, Ali A, Schulman MJ, Singh SB. Guttiferone I, a new prenylated benzophenone from Garcinia humilis as a liver X receptor ligand. J Nat Prod. 2005 Apr;68(4):617–619.
Published In
J Nat Prod
DOI
ISSN
0163-3864
Publication Date
April 2005
Volume
68
Issue
4
Start / End Page
617 / 619
Location
United States
Related Subject Headings
- Receptors, Cytoplasmic and Nuclear
- Orphan Nuclear Receptors
- Molecular Structure
- Medicinal & Biomolecular Chemistry
- Liver X Receptors
- Liver
- Ligands
- Inhibitory Concentration 50
- Garcinia
- DNA-Binding Proteins