Skip to main content
construction release_alert
Scholars@Duke will be undergoing maintenance April 11-15. Some features may be unavailable during this time.
cancel
Journal cover image

[Vesicular flow in epithelial cells: physiopathologic importance of two multiligand receptors].

Publication ,  Journal Article
Verroust, PJ; Christensen, EI; Hammond, TG
Published in: Bull Acad Natl Med
1996

Epithelial structures lining the proximal tubule and the yolk sac are characterized by a high rate of internalization followed by degradation of the proteins exposed to their apical pole. This function implies the expression by these epithelia of specialized proteins which have the ability to bind numerous ligands and/or lysosomal targeting properties. An improved knowledge of these molecules is needed since their expression in a limited number of epithelia may account for the specificity of some pathologies induced in particular by toxins. This paper deals with two such "candidate" proteins, gp330/megalin and gp280 which have been expressed in all species studied. gp280 is the target of teratogenic antibodies and is identified here as the receptor for intrinsic factor-cobalamin complexes but in all likelihood also binds other ligands. Antibodies to gp280 markedly stimulate the fusion of renal endosomes suggesting that it may play a role in targeting processes. gp330/megalin has been recently identified as the ligand of polybasic compounds such as gentamicin and is a key component in the internalization of the drug by tubular cells leading to renal toxicity. gp330/megalin also intervenes in endosomal fusion and some of its toxic properties may be mediated by this route.

Duke Scholars

Published In

Bull Acad Natl Med

ISSN

0001-4079

Publication Date

1996

Volume

180

Issue

6

Start / End Page

1187 / 1197

Location

Netherlands

Related Subject Headings

  • Vitamin B 12
  • Receptors, Peptide
  • Receptors, Cell Surface
  • Rats
  • Membrane Transport Proteins
  • Membrane Glycoproteins
  • General & Internal Medicine
  • Escherichia coli Proteins
  • Epithelium
  • Epithelial Cells
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Verroust, P. J., Christensen, E. I., & Hammond, T. G. (1996). [Vesicular flow in epithelial cells: physiopathologic importance of two multiligand receptors]. Bull Acad Natl Med, 180(6), 1187–1197.
Verroust, P. J., E. I. Christensen, and T. G. Hammond. “[Vesicular flow in epithelial cells: physiopathologic importance of two multiligand receptors].Bull Acad Natl Med 180, no. 6 (1996): 1187–97.
Verroust PJ, Christensen EI, Hammond TG. [Vesicular flow in epithelial cells: physiopathologic importance of two multiligand receptors]. Bull Acad Natl Med. 1996;180(6):1187–97.
Verroust, P. J., et al. “[Vesicular flow in epithelial cells: physiopathologic importance of two multiligand receptors].Bull Acad Natl Med, vol. 180, no. 6, 1996, pp. 1187–97.
Verroust PJ, Christensen EI, Hammond TG. [Vesicular flow in epithelial cells: physiopathologic importance of two multiligand receptors]. Bull Acad Natl Med. 1996;180(6):1187–1197.
Journal cover image

Published In

Bull Acad Natl Med

ISSN

0001-4079

Publication Date

1996

Volume

180

Issue

6

Start / End Page

1187 / 1197

Location

Netherlands

Related Subject Headings

  • Vitamin B 12
  • Receptors, Peptide
  • Receptors, Cell Surface
  • Rats
  • Membrane Transport Proteins
  • Membrane Glycoproteins
  • General & Internal Medicine
  • Escherichia coli Proteins
  • Epithelium
  • Epithelial Cells