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Gastroesophageal reflux disease-induced aspiration injury following lung transplantation.

Publication ,  Journal Article
Hartwig, MG; Davis, RD
Published in: Curr Opin Organ Transplant
October 2012

PURPOSE OF REVIEW: Chronic allograft failure remains the leading cause of late mortality following lung transplantation. Considerable evidence demonstrates a relationship between gastroesophageal reflux disease (GERD) induced allograft injury and bronchiolitis obliterans syndrome; however, the mechanism of injury, identification of at-risk patients, and treatment options remain to be elucidated. RECENT FINDINGS: The recent findings in this area help delineate the inflammatory pathways associated with GERD-induced lung injury. They also demonstrate that clinically useful markers of aspiration-induced injury may be available via studying bronchoalveolar fluid or even induced sputum. Simple acid neutralization is not adequate to protect these patients from aspiration injury. In fact, there are no convincing data to indicate that medical therapies provide adequate treatment. In contradistinction, surgical fundoplication is associated with decreased levels of inflammatory cytokines and markers of aspiration in bronchoalveolar fluid, as well as improvements in pulmonary function in these patients. SUMMARY: Recent findings support ubiquitous testing for GERD or aspiration in patients with end-stage lung disease both pretransplant and posttransplant and demonstrate that fundoplication can safely and effectively protect these patients from the on-going injury of GERD-induced pulmonary injury.

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Published In

Curr Opin Organ Transplant

DOI

EISSN

1531-7013

Publication Date

October 2012

Volume

17

Issue

5

Start / End Page

474 / 478

Location

United States

Related Subject Headings

  • Surgery
  • Lung Transplantation
  • Humans
  • Gastroesophageal Reflux
  • 3204 Immunology
  • 3202 Clinical sciences
  • 1107 Immunology
  • 1103 Clinical Sciences
  • 0903 Biomedical Engineering
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Hartwig, M. G., & Davis, R. D. (2012). Gastroesophageal reflux disease-induced aspiration injury following lung transplantation. Curr Opin Organ Transplant, 17(5), 474–478. https://doi.org/10.1097/MOT.0b013e328357f84f
Hartwig, Matthew G., and R Duane Davis. “Gastroesophageal reflux disease-induced aspiration injury following lung transplantation.Curr Opin Organ Transplant 17, no. 5 (October 2012): 474–78. https://doi.org/10.1097/MOT.0b013e328357f84f.
Hartwig MG, Davis RD. Gastroesophageal reflux disease-induced aspiration injury following lung transplantation. Curr Opin Organ Transplant. 2012 Oct;17(5):474–8.
Hartwig, Matthew G., and R. Duane Davis. “Gastroesophageal reflux disease-induced aspiration injury following lung transplantation.Curr Opin Organ Transplant, vol. 17, no. 5, Oct. 2012, pp. 474–78. Pubmed, doi:10.1097/MOT.0b013e328357f84f.
Hartwig MG, Davis RD. Gastroesophageal reflux disease-induced aspiration injury following lung transplantation. Curr Opin Organ Transplant. 2012 Oct;17(5):474–478.

Published In

Curr Opin Organ Transplant

DOI

EISSN

1531-7013

Publication Date

October 2012

Volume

17

Issue

5

Start / End Page

474 / 478

Location

United States

Related Subject Headings

  • Surgery
  • Lung Transplantation
  • Humans
  • Gastroesophageal Reflux
  • 3204 Immunology
  • 3202 Clinical sciences
  • 1107 Immunology
  • 1103 Clinical Sciences
  • 0903 Biomedical Engineering