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Endometrial cancer: multiplexed Luminex approaches for early detection.

Publication ,  Journal Article
Linkov, F; Yurkovetsky, Z; Taioli, E; Havrilesky, LJ; Maxwell, GL; Lokshin, A
Published in: Expert Opin Med Diagn
May 2008

BACKGROUND: Endometrial carcinoma is the most common gynecologic cancer. Despite the advances that have been made in other cancers, both the annual incidence of and the death rate associated with endometrial cancer appear to be rising, both in the US and around the world. In the US, ∼ 41,000 cases are diagnosed and about 7000 women die from the disease each year. Adenocarcinoma, which originates in surface cells of the endometrium, accounts for ∼ 90% of cases of endometrial cancer. At this time, there are no early detection tests or exams that can find endometrial cancer early in women without symptoms. OBJECTIVE: There is growing interest in the use of biomarker approaches for the early detection of endometrial cancer. Endometrial cancer has been linked to altered growth factor signaling, immune inflammatory responses and angiogenesis. This article provides an overview of endometrial cancer and outlines the rationale and need for the clinical application of multiplexed ELISA-based assays for the early detection of cancer. Although endometrial cancer has a generally favorable long-term outcome, its screening and diagnosis pose a challenge in women without symptoms. METHOD: An extensive literature review of biomarker approaches to endometrial cancer detection has been performed. Also, several studies conducted by the present team at the University of Pittsburgh Cancer Institute were reviewed. CONCLUSION: In the authors' published studies, it was hypothesized that an expanded panel of biomarkers comprised of cytokines, chemokines, growth factors and other tumor markers, which individually may show some promising correlation with disease status, might provide higher diagnostic power if used in combination, especially in the case of endometrial cancer detection. It was also discovered that prolactin may be very important for endometrial cancer detection. In this article, the potential clinical role for using multimarker testing in the early detection of endometrial cancer and for tumor surveillance to permit early identification of recurrence in patients with recurrent disease is discussed. Additionally, the role of lifestyle factors in the endometrial cancer development and prevention is discussed.

Duke Scholars

Published In

Expert Opin Med Diagn

DOI

ISSN

1753-0059

Publication Date

May 2008

Volume

2

Issue

5

Start / End Page

527 / 537

Location

England

Related Subject Headings

  • 3207 Medical microbiology
  • 3205 Medical biochemistry and metabolomics
  • 3202 Clinical sciences
  • 1108 Medical Microbiology
  • 1103 Clinical Sciences
  • 1101 Medical Biochemistry and Metabolomics
 

Citation

APA
Chicago
ICMJE
MLA
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Linkov, F., Yurkovetsky, Z., Taioli, E., Havrilesky, L. J., Maxwell, G. L., & Lokshin, A. (2008). Endometrial cancer: multiplexed Luminex approaches for early detection. Expert Opin Med Diagn, 2(5), 527–537. https://doi.org/10.1517/17530059.2.5.527
Linkov, Faina, Zoya Yurkovetsky, Emanuela Taioli, Laura J. Havrilesky, G Larry Maxwell, and Anna Lokshin. “Endometrial cancer: multiplexed Luminex approaches for early detection.Expert Opin Med Diagn 2, no. 5 (May 2008): 527–37. https://doi.org/10.1517/17530059.2.5.527.
Linkov F, Yurkovetsky Z, Taioli E, Havrilesky LJ, Maxwell GL, Lokshin A. Endometrial cancer: multiplexed Luminex approaches for early detection. Expert Opin Med Diagn. 2008 May;2(5):527–37.
Linkov, Faina, et al. “Endometrial cancer: multiplexed Luminex approaches for early detection.Expert Opin Med Diagn, vol. 2, no. 5, May 2008, pp. 527–37. Pubmed, doi:10.1517/17530059.2.5.527.
Linkov F, Yurkovetsky Z, Taioli E, Havrilesky LJ, Maxwell GL, Lokshin A. Endometrial cancer: multiplexed Luminex approaches for early detection. Expert Opin Med Diagn. 2008 May;2(5):527–537.

Published In

Expert Opin Med Diagn

DOI

ISSN

1753-0059

Publication Date

May 2008

Volume

2

Issue

5

Start / End Page

527 / 537

Location

England

Related Subject Headings

  • 3207 Medical microbiology
  • 3205 Medical biochemistry and metabolomics
  • 3202 Clinical sciences
  • 1108 Medical Microbiology
  • 1103 Clinical Sciences
  • 1101 Medical Biochemistry and Metabolomics