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Structural plasticity of dentate granule cell mossy fibers during the development of limbic epilepsy.

Publication ,  Journal Article
Danzer, SC; He, X; Loepke, AW; McNamara, JO
Published in: Hippocampus
January 2010

Altered granule cell>>CA3 pyramidal cell synaptic connectivity may contribute to the development of limbic epilepsy. To explore this possibility, granule cell giant mossy fiber bouton plasticity was examined in the kindling and pilocarpine models of epilepsy using green fluorescent protein-expressing transgenic mice. These studies revealed significant increases in the frequency of giant boutons with satellite boutons 2 days and 1 month after pilocarpine status epilepticus, and increases in giant bouton area at 1 month. Similar increases in giant bouton area were observed shortly after kindling. Finally, both models exhibited plasticity of mossy fiber giant bouton filopodia, which contact GABAergic interneurons mediating feedforward inhibition of CA3 pyramids. In the kindling model, however, all changes were fleeting, having resolved by 1 month after the last evoked seizure. Together, these findings demonstrate striking structural plasticity of granule cell mossy fiber synaptic terminal structure in two distinct models of adult limbic epileptogenesis. We suggest that these plasticities modify local connectivities between individual mossy fiber terminals and their targets, inhibitory interneurons, and CA3 pyramidal cells potentially altering the balance of excitation and inhibition during the development of epilepsy.

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Published In

Hippocampus

DOI

EISSN

1098-1063

Publication Date

January 2010

Volume

20

Issue

1

Start / End Page

113 / 124

Location

United States

Related Subject Headings

  • gamma-Aminobutyric Acid
  • Pyramidal Cells
  • Pseudopodia
  • Presynaptic Terminals
  • Neurons
  • Neuronal Plasticity
  • Neurology & Neurosurgery
  • Neural Inhibition
  • Mossy Fibers, Hippocampal
  • Mice, Transgenic
 

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Danzer, S. C., He, X., Loepke, A. W., & McNamara, J. O. (2010). Structural plasticity of dentate granule cell mossy fibers during the development of limbic epilepsy. Hippocampus, 20(1), 113–124. https://doi.org/10.1002/hipo.20589
Danzer, Steve C., Xiaoping He, Andreas W. Loepke, and James O. McNamara. “Structural plasticity of dentate granule cell mossy fibers during the development of limbic epilepsy.Hippocampus 20, no. 1 (January 2010): 113–24. https://doi.org/10.1002/hipo.20589.
Danzer SC, He X, Loepke AW, McNamara JO. Structural plasticity of dentate granule cell mossy fibers during the development of limbic epilepsy. Hippocampus. 2010 Jan;20(1):113–24.
Danzer, Steve C., et al. “Structural plasticity of dentate granule cell mossy fibers during the development of limbic epilepsy.Hippocampus, vol. 20, no. 1, Jan. 2010, pp. 113–24. Pubmed, doi:10.1002/hipo.20589.
Danzer SC, He X, Loepke AW, McNamara JO. Structural plasticity of dentate granule cell mossy fibers during the development of limbic epilepsy. Hippocampus. 2010 Jan;20(1):113–124.
Journal cover image

Published In

Hippocampus

DOI

EISSN

1098-1063

Publication Date

January 2010

Volume

20

Issue

1

Start / End Page

113 / 124

Location

United States

Related Subject Headings

  • gamma-Aminobutyric Acid
  • Pyramidal Cells
  • Pseudopodia
  • Presynaptic Terminals
  • Neurons
  • Neuronal Plasticity
  • Neurology & Neurosurgery
  • Neural Inhibition
  • Mossy Fibers, Hippocampal
  • Mice, Transgenic