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Mitochondrial protein acetylation regulates metabolism.

Publication ,  Journal Article
Anderson, KA; Hirschey, MD
Published in: Essays Biochem
2012

Changes in cellular nutrient availability or energy status induce global changes in mitochondrial protein acetylation. Over one-third of all proteins in the mitochondria are acetylated, of which the majority are involved in some aspect of energy metabolism. Mitochondrial protein acetylation is regulated by SIRT3 (sirtuin 3), a member of the sirtuin family of NAD+-dependent protein deacetylases that has recently been identified as a key modulator of energy homoeostasis. In the absence of SIRT3, mitochondrial proteins become hyperacetylated, have altered function, and contribute to mitochondrial dysfunction. This chapter presents a review of the functional impact of mitochondrial protein acetylation, and its regulation by SIRT3.

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Published In

Essays Biochem

DOI

EISSN

1744-1358

Publication Date

2012

Volume

52

Start / End Page

23 / 35

Location

England

Related Subject Headings

  • Sirtuin 3
  • Models, Biological
  • Mitochondrial Proteins
  • Mitochondria
  • Humans
  • Biochemistry & Molecular Biology
  • Animals
  • Acetylation
  • 3101 Biochemistry and cell biology
  • 0601 Biochemistry and Cell Biology
 

Citation

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Anderson, K. A., & Hirschey, M. D. (2012). Mitochondrial protein acetylation regulates metabolism. Essays Biochem, 52, 23–35. https://doi.org/10.1042/bse0520023
Anderson, Kristin A., and Matthew D. Hirschey. “Mitochondrial protein acetylation regulates metabolism.Essays Biochem 52 (2012): 23–35. https://doi.org/10.1042/bse0520023.
Anderson KA, Hirschey MD. Mitochondrial protein acetylation regulates metabolism. Essays Biochem. 2012;52:23–35.
Anderson, Kristin A., and Matthew D. Hirschey. “Mitochondrial protein acetylation regulates metabolism.Essays Biochem, vol. 52, 2012, pp. 23–35. Pubmed, doi:10.1042/bse0520023.
Anderson KA, Hirschey MD. Mitochondrial protein acetylation regulates metabolism. Essays Biochem. 2012;52:23–35.

Published In

Essays Biochem

DOI

EISSN

1744-1358

Publication Date

2012

Volume

52

Start / End Page

23 / 35

Location

England

Related Subject Headings

  • Sirtuin 3
  • Models, Biological
  • Mitochondrial Proteins
  • Mitochondria
  • Humans
  • Biochemistry & Molecular Biology
  • Animals
  • Acetylation
  • 3101 Biochemistry and cell biology
  • 0601 Biochemistry and Cell Biology