Mitochondrial protein acetylation regulates metabolism.
Publication
, Journal Article
Anderson, KA; Hirschey, MD
Published in: Essays Biochem
2012
Changes in cellular nutrient availability or energy status induce global changes in mitochondrial protein acetylation. Over one-third of all proteins in the mitochondria are acetylated, of which the majority are involved in some aspect of energy metabolism. Mitochondrial protein acetylation is regulated by SIRT3 (sirtuin 3), a member of the sirtuin family of NAD+-dependent protein deacetylases that has recently been identified as a key modulator of energy homoeostasis. In the absence of SIRT3, mitochondrial proteins become hyperacetylated, have altered function, and contribute to mitochondrial dysfunction. This chapter presents a review of the functional impact of mitochondrial protein acetylation, and its regulation by SIRT3.
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Published In
Essays Biochem
DOI
EISSN
1744-1358
Publication Date
2012
Volume
52
Start / End Page
23 / 35
Location
England
Related Subject Headings
- Sirtuin 3
- Models, Biological
- Mitochondrial Proteins
- Mitochondria
- Humans
- Biochemistry & Molecular Biology
- Animals
- Acetylation
- 3101 Biochemistry and cell biology
- 0601 Biochemistry and Cell Biology
Citation
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ICMJE
MLA
NLM
Anderson, K. A., & Hirschey, M. D. (2012). Mitochondrial protein acetylation regulates metabolism. Essays Biochem, 52, 23–35. https://doi.org/10.1042/bse0520023
Anderson, Kristin A., and Matthew D. Hirschey. “Mitochondrial protein acetylation regulates metabolism.” Essays Biochem 52 (2012): 23–35. https://doi.org/10.1042/bse0520023.
Anderson KA, Hirschey MD. Mitochondrial protein acetylation regulates metabolism. Essays Biochem. 2012;52:23–35.
Anderson, Kristin A., and Matthew D. Hirschey. “Mitochondrial protein acetylation regulates metabolism.” Essays Biochem, vol. 52, 2012, pp. 23–35. Pubmed, doi:10.1042/bse0520023.
Anderson KA, Hirschey MD. Mitochondrial protein acetylation regulates metabolism. Essays Biochem. 2012;52:23–35.
Published In
Essays Biochem
DOI
EISSN
1744-1358
Publication Date
2012
Volume
52
Start / End Page
23 / 35
Location
England
Related Subject Headings
- Sirtuin 3
- Models, Biological
- Mitochondrial Proteins
- Mitochondria
- Humans
- Biochemistry & Molecular Biology
- Animals
- Acetylation
- 3101 Biochemistry and cell biology
- 0601 Biochemistry and Cell Biology