Skip to main content
Journal cover image

Preparing for the first breath: genetic and cellular mechanisms in lung development.

Publication ,  Journal Article
Morrisey, EE; Hogan, BLM
Published in: Dev Cell
January 19, 2010

The mammalian respiratory system--the trachea and the lungs--arises from the anterior foregut through a sequence of morphogenetic events involving reciprocal endodermal-mesodermal interactions. The lung itself consists of two highly branched, tree-like systems--the airways and the vasculature--that develop in a coordinated way from the primary bud stage to the generation of millions of alveolar gas exchange units. We are beginning to understand some of the molecular and cellular mechanisms that underlie critical processes such as branching morphogenesis, vascular development, and the differentiation of multipotent progenitor populations. Nevertheless, many gaps remain in our knowledge, the filling of which is essential for understanding respiratory disorders, congenital defects in human neonates, and how the disruption of morphogenetic programs early in lung development can lead to deficiencies that persist throughout life.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Dev Cell

DOI

EISSN

1878-1551

Publication Date

January 19, 2010

Volume

18

Issue

1

Start / End Page

8 / 23

Location

United States

Related Subject Headings

  • Stem Cells
  • Pulmonary Artery
  • Organogenesis
  • Myocytes, Smooth Muscle
  • Lung Diseases
  • Lung
  • Gene Expression Regulation, Developmental
  • Epithelial Cells
  • Developmental Biology
  • Cell Differentiation
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Morrisey, E. E., & Hogan, B. L. M. (2010). Preparing for the first breath: genetic and cellular mechanisms in lung development. Dev Cell, 18(1), 8–23. https://doi.org/10.1016/j.devcel.2009.12.010
Morrisey, Edward E., and Brigid L. M. Hogan. “Preparing for the first breath: genetic and cellular mechanisms in lung development.Dev Cell 18, no. 1 (January 19, 2010): 8–23. https://doi.org/10.1016/j.devcel.2009.12.010.
Morrisey EE, Hogan BLM. Preparing for the first breath: genetic and cellular mechanisms in lung development. Dev Cell. 2010 Jan 19;18(1):8–23.
Morrisey, Edward E., and Brigid L. M. Hogan. “Preparing for the first breath: genetic and cellular mechanisms in lung development.Dev Cell, vol. 18, no. 1, Jan. 2010, pp. 8–23. Pubmed, doi:10.1016/j.devcel.2009.12.010.
Morrisey EE, Hogan BLM. Preparing for the first breath: genetic and cellular mechanisms in lung development. Dev Cell. 2010 Jan 19;18(1):8–23.
Journal cover image

Published In

Dev Cell

DOI

EISSN

1878-1551

Publication Date

January 19, 2010

Volume

18

Issue

1

Start / End Page

8 / 23

Location

United States

Related Subject Headings

  • Stem Cells
  • Pulmonary Artery
  • Organogenesis
  • Myocytes, Smooth Muscle
  • Lung Diseases
  • Lung
  • Gene Expression Regulation, Developmental
  • Epithelial Cells
  • Developmental Biology
  • Cell Differentiation