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The role of the forkhead transcription factor, Foxc1, in the development of the mouse lacrimal gland.

Publication ,  Journal Article
Mattiske, D; Sommer, P; Kidson, SH; Hogan, BLM
Published in: Dev Dyn
April 2006

The lacrimal gland produces secretions that lubricate and protect the cornea of the eye. Foxc1 encodes a forkhead/winged helix transcription factor required for the development of many embryonic organs. Autosomal dominant mutations in human FOXC1 cause eye disorders such as Axenfeld-Rieger Syndrome and glaucoma iris hypoplasia, resulting from malformation of the anterior segment of the eye. We show here that lacrimal gland development is severely impaired in homozygous null Foxc1 mouse mutants, with reduced outgrowth and branching. Foxc1 is expressed in both the epithelium of the lacrimal gland and the surrounding mesenchyme. FGF10 stimulates the growth and branching morphogenesis in cultures of wild type and Foxc1 mutant gland epithelial buds. However, using micromass culture of lacrimal gland mesenchyme, we show that Bmp7 induces wild type mesenchyme cells to aggregate, but Foxc1 mutant cells do not respond. This study demonstrates that Foxc1 mediates the BMP signaling required for lacrimal gland development.

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Published In

Dev Dyn

DOI

ISSN

1058-8388

Publication Date

April 2006

Volume

235

Issue

4

Start / End Page

1074 / 1080

Location

United States

Related Subject Headings

  • beta-Galactosidase
  • Transforming Growth Factor beta
  • Organ Culture Techniques
  • Mutation
  • Morphogenesis
  • Mice, Knockout
  • Mice
  • Mesoderm
  • Lacrimal Apparatus
  • In Situ Hybridization
 

Citation

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Mattiske, D., Sommer, P., Kidson, S. H., & Hogan, B. L. M. (2006). The role of the forkhead transcription factor, Foxc1, in the development of the mouse lacrimal gland. Dev Dyn, 235(4), 1074–1080. https://doi.org/10.1002/dvdy.20702
Mattiske, Deidre, Paula Sommer, Susan H. Kidson, and Brigid L. M. Hogan. “The role of the forkhead transcription factor, Foxc1, in the development of the mouse lacrimal gland.Dev Dyn 235, no. 4 (April 2006): 1074–80. https://doi.org/10.1002/dvdy.20702.
Mattiske D, Sommer P, Kidson SH, Hogan BLM. The role of the forkhead transcription factor, Foxc1, in the development of the mouse lacrimal gland. Dev Dyn. 2006 Apr;235(4):1074–80.
Mattiske, Deidre, et al. “The role of the forkhead transcription factor, Foxc1, in the development of the mouse lacrimal gland.Dev Dyn, vol. 235, no. 4, Apr. 2006, pp. 1074–80. Pubmed, doi:10.1002/dvdy.20702.
Mattiske D, Sommer P, Kidson SH, Hogan BLM. The role of the forkhead transcription factor, Foxc1, in the development of the mouse lacrimal gland. Dev Dyn. 2006 Apr;235(4):1074–1080.
Journal cover image

Published In

Dev Dyn

DOI

ISSN

1058-8388

Publication Date

April 2006

Volume

235

Issue

4

Start / End Page

1074 / 1080

Location

United States

Related Subject Headings

  • beta-Galactosidase
  • Transforming Growth Factor beta
  • Organ Culture Techniques
  • Mutation
  • Morphogenesis
  • Mice, Knockout
  • Mice
  • Mesoderm
  • Lacrimal Apparatus
  • In Situ Hybridization