Skip to main content
construction release_alert
Scholars@Duke will be undergoing maintenance April 11-15. Some features may be unavailable during this time.
cancel
Journal cover image

Residual symptoms in older patients treated for major depression.

Publication ,  Journal Article
Hybels, CF; Steffens, DC; McQuoid, DR; Rama Krishnan, KR
Published in: Int J Geriatr Psychiatry
December 2005

OBJECTIVE: The purpose of this study was to identify residual symptoms in a sample of older adults treated for major depression and compare individual symptoms present at baseline with those at three months by remission status. METHODS: The sample was comprised of 229 patients with DSM-IV major depression who were participants in the NIMH Mental Health Clinical Research Center at Duke University. Symptoms were measured using the Montgomery-Asberg Depression Rating Scale (MADRS). RESULTS: At three months, 86 patients (37.6%) had remitted, or had a MADRS score less than or equal to 9. In the remitted group, the most frequently reported symptoms at three months were inner tension and lassitude. Among nonremitters, the most frequently reported symptoms were reported and apparent sadness, as well as lassitude and inner tension. In the sample as a whole, the symptoms most likely to be present at baseline but not three months were pessimistic and suicidal thoughts, while the most frequently reported emergent symptoms were reduced appetite and inner tension. Patients were much more likely to no longer have a particular symptom than to acquire a new symptom. Overall, the symptoms present at three months were not severe in either group. CONCLUSIONS: In older adults treated for major depression, residual symptoms at three months may include emergent symptoms as well as persistent symptoms, and are likely to include symptoms of anxiety as well as sadness. These findings have clinical implications for the treatment of late-life depression.

Duke Scholars

Published In

Int J Geriatr Psychiatry

DOI

ISSN

0885-6230

Publication Date

December 2005

Volume

20

Issue

12

Start / End Page

1196 / 1202

Location

England

Related Subject Headings

  • Treatment Outcome
  • Psychiatric Status Rating Scales
  • Prospective Studies
  • Middle Aged
  • Male
  • Humans
  • Geriatrics
  • Follow-Up Studies
  • Female
  • Diagnostic and Statistical Manual of Mental Disorders
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Hybels, C. F., Steffens, D. C., McQuoid, D. R., & Rama Krishnan, K. R. (2005). Residual symptoms in older patients treated for major depression. Int J Geriatr Psychiatry, 20(12), 1196–1202. https://doi.org/10.1002/gps.1418
Hybels, Celia F., David C. Steffens, Douglas R. McQuoid, and K Ranga Rama Krishnan. “Residual symptoms in older patients treated for major depression.Int J Geriatr Psychiatry 20, no. 12 (December 2005): 1196–1202. https://doi.org/10.1002/gps.1418.
Hybels CF, Steffens DC, McQuoid DR, Rama Krishnan KR. Residual symptoms in older patients treated for major depression. Int J Geriatr Psychiatry. 2005 Dec;20(12):1196–202.
Hybels, Celia F., et al. “Residual symptoms in older patients treated for major depression.Int J Geriatr Psychiatry, vol. 20, no. 12, Dec. 2005, pp. 1196–202. Pubmed, doi:10.1002/gps.1418.
Hybels CF, Steffens DC, McQuoid DR, Rama Krishnan KR. Residual symptoms in older patients treated for major depression. Int J Geriatr Psychiatry. 2005 Dec;20(12):1196–1202.
Journal cover image

Published In

Int J Geriatr Psychiatry

DOI

ISSN

0885-6230

Publication Date

December 2005

Volume

20

Issue

12

Start / End Page

1196 / 1202

Location

England

Related Subject Headings

  • Treatment Outcome
  • Psychiatric Status Rating Scales
  • Prospective Studies
  • Middle Aged
  • Male
  • Humans
  • Geriatrics
  • Follow-Up Studies
  • Female
  • Diagnostic and Statistical Manual of Mental Disorders