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Systemic oxidative stress, as measured by urinary allantoin and F(2)-isoprostanes, is not increased in Down syndrome.

Publication ,  Journal Article
Tolun, AA; Scarbrough, PM; Zhang, H; McKillop, J-A; Wang, F; Kishnani, PS; Millington, DS; Young, SP; Il'yasova, D
Published in: Ann Epidemiol
December 2012
Published version (DOI) Link to item

PURPOSE: Oxidative stress has been implicated in Down syndrome (DS) pathology. This study compares DS individuals and controls on their urinary levels of allantoin and 2,3-dinor-iPF2α-III; these biomarkers have been previously validated in a clinical model of oxidative stress. METHODS: Urine samples were collected from 48 individuals with DS and 130 controls. Biomarkers were assayed by ultraperformance liquid chromatography-tandem mass spectrometry, normalized by urinary creatinine concentration. RESULTS: After adjusting for age and gender, mean allantoin levels were lower among DS individuals versus controls (P = .04). The adjusted mean levels of 2,3-dinor-iPF2α-III were similar in DS individuals and controls (P = .7). CONCLUSIONS: Our results do not support the hypothesis that DS individuals have chronic systemic oxidative stress.

Duke Scholars

Priya Sunil Kishnani
Author Priya Sunil Kishnani Pediatrics, Medical Genetics
David Stuart Millington
Author David Stuart Millington Pediatrics, Medical Genetics
Sarah Phyllis Young
Author Sarah Phyllis Young Pediatrics, Medical Genetics

Published In

Ann Epidemiol

DOI

10.1016/j.annepidem.2012.09.005

EISSN

1873-2585

Publication Date

December 2012

Volume

22

Issue

12

Start / End Page

892 / 894

Location

United States

Related Subject Headings

  • Young Adult
  • Tandem Mass Spectrometry
  • Oxidative Stress
  • Middle Aged
  • Male
  • Humans
  • Female
  • F2-Isoprostanes
  • Epidemiology
  • Down Syndrome
 

Citation

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MLA
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Tolun, A. A., Scarbrough, P. M., Zhang, H., McKillop, J.-A., Wang, F., Kishnani, P. S., … Il’yasova, D. (2012). Systemic oxidative stress, as measured by urinary allantoin and F(2)-isoprostanes, is not increased in Down syndrome. Ann Epidemiol, 22(12), 892–894. https://doi.org/10.1016/j.annepidem.2012.09.005
Tolun, Adviye A., Peter M. Scarbrough, Haoyue Zhang, Jane-Ann McKillop, Frances Wang, Priya S. Kishnani, David S. Millington, Sarah P. Young, and Dora Il’yasova. “Systemic oxidative stress, as measured by urinary allantoin and F(2)-isoprostanes, is not increased in Down syndrome.” Ann Epidemiol 22, no. 12 (December 2012): 892–94. https://doi.org/10.1016/j.annepidem.2012.09.005.
Tolun AA, Scarbrough PM, Zhang H, McKillop J-A, Wang F, Kishnani PS, et al. Systemic oxidative stress, as measured by urinary allantoin and F(2)-isoprostanes, is not increased in Down syndrome. Ann Epidemiol. 2012 Dec;22(12):892–4.
Tolun, Adviye A., et al. “Systemic oxidative stress, as measured by urinary allantoin and F(2)-isoprostanes, is not increased in Down syndrome.” Ann Epidemiol, vol. 22, no. 12, Dec. 2012, pp. 892–94. Pubmed, doi:10.1016/j.annepidem.2012.09.005.
Tolun AA, Scarbrough PM, Zhang H, McKillop J-A, Wang F, Kishnani PS, Millington DS, Young SP, Il’yasova D. Systemic oxidative stress, as measured by urinary allantoin and F(2)-isoprostanes, is not increased in Down syndrome. Ann Epidemiol. 2012 Dec;22(12):892–894.
Journal cover image

Published In

Ann Epidemiol

DOI

10.1016/j.annepidem.2012.09.005

EISSN

1873-2585

Publication Date

December 2012

Volume

22

Issue

12

Start / End Page

892 / 894

Location

United States

Related Subject Headings

  • Young Adult
  • Tandem Mass Spectrometry
  • Oxidative Stress
  • Middle Aged
  • Male
  • Humans
  • Female
  • F2-Isoprostanes
  • Epidemiology
  • Down Syndrome