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Matrix metalloprotease regulation of neuropathic pain.

Publication ,  Journal Article
Ji, R-R; Xu, Z-Z; Wang, X; Lo, EH
Published in: Trends Pharmacol Sci
July 2009

Neuropathic pain affects millions of people globally and could be a disease on its own right. Current treatments focus on blocking neurotransmission and have resulted in limited success. Recent progress points to an important role of neuroinflammation in the pathogenesis of neuropathic pain. Matrix metalloproteases (MMPs) comprise a large family of zinc endopeptidases that have been implicated in the generation of neuroinflammation via cleavage of extracellular matrix proteins and activation of proinflammatory cytokines and chemokines. However, little is known about the role of MMPs in chronic pain regulation. Our recent study has shown that neuropathic pain development in the early and late phase requires MMP-9 and MMP-2, respectively. Inhibition of MMP-9 or MMP-2 might provide a new strategy for the prevention and treatment of neuropathic pain.

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Published In

Trends Pharmacol Sci

DOI

EISSN

1873-3735

Publication Date

July 2009

Volume

30

Issue

7

Start / End Page

336 / 340

Location

England

Related Subject Headings

  • Protease Inhibitors
  • Pharmacology & Pharmacy
  • Pain
  • Neuralgia
  • Matrix Metalloproteinases
  • Matrix Metalloproteinase Inhibitors
  • Matrix Metalloproteinase 9
  • Matrix Metalloproteinase 2
  • Humans
  • Animals
 

Citation

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Ji, R.-R., Xu, Z.-Z., Wang, X., & Lo, E. H. (2009). Matrix metalloprotease regulation of neuropathic pain. Trends Pharmacol Sci, 30(7), 336–340. https://doi.org/10.1016/j.tips.2009.04.002
Ji, Ru-Rong, Zhen-Zhong Xu, Xiaoying Wang, and Eng H. Lo. “Matrix metalloprotease regulation of neuropathic pain.Trends Pharmacol Sci 30, no. 7 (July 2009): 336–40. https://doi.org/10.1016/j.tips.2009.04.002.
Ji R-R, Xu Z-Z, Wang X, Lo EH. Matrix metalloprotease regulation of neuropathic pain. Trends Pharmacol Sci. 2009 Jul;30(7):336–40.
Ji, Ru-Rong, et al. “Matrix metalloprotease regulation of neuropathic pain.Trends Pharmacol Sci, vol. 30, no. 7, July 2009, pp. 336–40. Pubmed, doi:10.1016/j.tips.2009.04.002.
Ji R-R, Xu Z-Z, Wang X, Lo EH. Matrix metalloprotease regulation of neuropathic pain. Trends Pharmacol Sci. 2009 Jul;30(7):336–340.
Journal cover image

Published In

Trends Pharmacol Sci

DOI

EISSN

1873-3735

Publication Date

July 2009

Volume

30

Issue

7

Start / End Page

336 / 340

Location

England

Related Subject Headings

  • Protease Inhibitors
  • Pharmacology & Pharmacy
  • Pain
  • Neuralgia
  • Matrix Metalloproteinases
  • Matrix Metalloproteinase Inhibitors
  • Matrix Metalloproteinase 9
  • Matrix Metalloproteinase 2
  • Humans
  • Animals