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Nociceptors are interleukin-1beta sensors.

Publication ,  Journal Article
Binshtok, AM; Wang, H; Zimmermann, K; Amaya, F; Vardeh, D; Shi, L; Brenner, GJ; Ji, R-R; Bean, BP; Woolf, CJ; Samad, TA
Published in: J Neurosci
December 24, 2008

A cardinal feature of inflammation is heightened pain sensitivity at the site of the inflamed tissue. This results from the local release by immune and injured cells of nociceptor sensitizers, including prostaglandin E(2), bradykinin, and nerve growth factor, that reduce the threshold and increase the excitability of the peripheral terminals of nociceptors so that they now respond to innocuous stimuli: the phenomenon of peripheral sensitization. We show here that the proinflammatory cytokine interleukin-1beta (IL-1beta), in addition to producing inflammation and inducing synthesis of several nociceptor sensitizers, also rapidly and directly activates nociceptors to generate action potentials and induce pain hypersensitivity. IL-1beta acts in a p38 mitogen-activated protein kinase (p38 MAP kinase)-dependent manner, to increase the excitability of nociceptors by relieving resting slow inactivation of tetrodotoxin-resistant voltage-gated sodium channels and also enhances persistent TTX-resistant current near threshold. By acting as an IL-1beta sensor, nociceptors can directly signal the presence of ongoing tissue inflammation.

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Published In

J Neurosci

DOI

EISSN

1529-2401

Publication Date

December 24, 2008

Volume

28

Issue

52

Start / End Page

14062 / 14073

Location

United States

Related Subject Headings

  • p38 Mitogen-Activated Protein Kinases
  • Time Factors
  • Tetrodotoxin
  • Sodium Channel Blockers
  • Sensory Receptor Cells
  • Rats, Sprague-Dawley
  • Rats
  • Pyridines
  • Physical Stimulation
  • Peripherins
 

Citation

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MLA
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Binshtok, A. M., Wang, H., Zimmermann, K., Amaya, F., Vardeh, D., Shi, L., … Samad, T. A. (2008). Nociceptors are interleukin-1beta sensors. The Journal of Neuroscience : The Official Journal of the Society for Neuroscience, 28(52), 14062–14073. https://doi.org/10.1523/jneurosci.3795-08.2008
Binshtok, Alexander M., Haibin Wang, Katharina Zimmermann, Fumimasa Amaya, Daniel Vardeh, Lin Shi, Gary J. Brenner, et al. “Nociceptors are interleukin-1beta sensors.The Journal of Neuroscience : The Official Journal of the Society for Neuroscience 28, no. 52 (December 2008): 14062–73. https://doi.org/10.1523/jneurosci.3795-08.2008.
Binshtok AM, Wang H, Zimmermann K, Amaya F, Vardeh D, Shi L, et al. Nociceptors are interleukin-1beta sensors. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2008 Dec;28(52):14062–73.
Binshtok, Alexander M., et al. “Nociceptors are interleukin-1beta sensors.The Journal of Neuroscience : The Official Journal of the Society for Neuroscience, vol. 28, no. 52, Dec. 2008, pp. 14062–73. Epmc, doi:10.1523/jneurosci.3795-08.2008.
Binshtok AM, Wang H, Zimmermann K, Amaya F, Vardeh D, Shi L, Brenner GJ, Ji R-R, Bean BP, Woolf CJ, Samad TA. Nociceptors are interleukin-1beta sensors. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2008 Dec;28(52):14062–14073.

Published In

J Neurosci

DOI

EISSN

1529-2401

Publication Date

December 24, 2008

Volume

28

Issue

52

Start / End Page

14062 / 14073

Location

United States

Related Subject Headings

  • p38 Mitogen-Activated Protein Kinases
  • Time Factors
  • Tetrodotoxin
  • Sodium Channel Blockers
  • Sensory Receptor Cells
  • Rats, Sprague-Dawley
  • Rats
  • Pyridines
  • Physical Stimulation
  • Peripherins