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p38 MAPK, microglial signaling, and neuropathic pain.

Publication ,  Journal Article
Ji, R-R; Suter, MR
Published in: Mol Pain
November 1, 2007

Accumulating evidence over last several years indicates an important role of microglial cells in the pathogenesis of neuropathic pain. Signal transduction in microglia under chronic pain states has begun to be revealed. We will review the evidence that p38 MAPK is activated in spinal microglia after nerve injury and contributes importantly to neuropathic pain development and maintenance. We will discuss the upstream mechanisms causing p38 activation in spinal microglia after nerve injury. We will also discuss the downstream mechanisms by which p38 produces inflammatory mediators. Taken together, current data suggest that p38 plays a critical role in microglial signaling under neuropathic pain conditions and represents a valuable therapeutic target for neuropathic pain management.

Duke Scholars

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Published In

Mol Pain

DOI

EISSN

1744-8069

Publication Date

November 1, 2007

Volume

3

Start / End Page

33

Location

United States

Related Subject Headings

  • p38 Mitogen-Activated Protein Kinases
  • Spinal Nerves
  • Spinal Cord
  • Signal Transduction
  • Receptors, Chemokine
  • Rats
  • Pyridines
  • Pyrazoles
  • Pain Measurement
  • Neurology & Neurosurgery
 

Citation

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Ji, R.-R., & Suter, M. R. (2007). p38 MAPK, microglial signaling, and neuropathic pain. Mol Pain, 3, 33. https://doi.org/10.1186/1744-8069-3-33
Ji, Ru-Rong, and Marc R. Suter. “p38 MAPK, microglial signaling, and neuropathic pain.Mol Pain 3 (November 1, 2007): 33. https://doi.org/10.1186/1744-8069-3-33.
Ji R-R, Suter MR. p38 MAPK, microglial signaling, and neuropathic pain. Mol Pain. 2007 Nov 1;3:33.
Ji, Ru-Rong, and Marc R. Suter. “p38 MAPK, microglial signaling, and neuropathic pain.Mol Pain, vol. 3, Nov. 2007, p. 33. Pubmed, doi:10.1186/1744-8069-3-33.
Ji R-R, Suter MR. p38 MAPK, microglial signaling, and neuropathic pain. Mol Pain. 2007 Nov 1;3:33.
Journal cover image

Published In

Mol Pain

DOI

EISSN

1744-8069

Publication Date

November 1, 2007

Volume

3

Start / End Page

33

Location

United States

Related Subject Headings

  • p38 Mitogen-Activated Protein Kinases
  • Spinal Nerves
  • Spinal Cord
  • Signal Transduction
  • Receptors, Chemokine
  • Rats
  • Pyridines
  • Pyrazoles
  • Pain Measurement
  • Neurology & Neurosurgery