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Mitogen-activated protein kinases as potential targets for pain killers.

Publication ,  Journal Article
Ji, R-R
Published in: Curr Opin Investig Drugs
January 2004

Pathological pain, such as inflammatory and neuropathic pain, is an expression of neural plasticity. Mitogen-activated protein kinases (MAPKs) play an important role in neural plasticity via post-translational, translational and transcriptional regulation. Under conditions of tissue and nerve damage, extracellular signal-regulated kinase (ERK) and p38 MAPK can be activated by nociceptive activity and inflammatory mediators in primary sensory neurons in the peripheral nervous system, and spinal cord neurons and glia in the central nervous system. Activation of ERK in dorsal horn neurons is nociceptive-specific and suppressed by several analgesics, and therefore has potential for the development of an assay to test the efficacy of new analgesics. Inhibition of ERK or p38 alleviates inflammatory pain and neuropathic pain in animal models. Development of specific inhibitors for these two MAPKs may lead to new therapies for pathological pain.

Duke Scholars

Published In

Curr Opin Investig Drugs

ISSN

1472-4472

Publication Date

January 2004

Volume

5

Issue

1

Start / End Page

71 / 75

Location

England

Related Subject Headings

  • Structure-Activity Relationship
  • Pharmacology & Pharmacy
  • Peripheral Nervous System Diseases
  • Pain
  • Mitogen-Activated Protein Kinases
  • Inflammation
  • Humans
  • Enzyme Inhibitors
  • Enzyme Activation
  • Drug Design
 

Citation

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MLA
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Ji, R.-R. (2004). Mitogen-activated protein kinases as potential targets for pain killers. Curr Opin Investig Drugs, 5(1), 71–75.
Ji, Ru-Rong. “Mitogen-activated protein kinases as potential targets for pain killers.Curr Opin Investig Drugs 5, no. 1 (January 2004): 71–75.
Ji R-R. Mitogen-activated protein kinases as potential targets for pain killers. Curr Opin Investig Drugs. 2004 Jan;5(1):71–5.
Ji, Ru-Rong. “Mitogen-activated protein kinases as potential targets for pain killers.Curr Opin Investig Drugs, vol. 5, no. 1, Jan. 2004, pp. 71–75.
Ji R-R. Mitogen-activated protein kinases as potential targets for pain killers. Curr Opin Investig Drugs. 2004 Jan;5(1):71–75.

Published In

Curr Opin Investig Drugs

ISSN

1472-4472

Publication Date

January 2004

Volume

5

Issue

1

Start / End Page

71 / 75

Location

England

Related Subject Headings

  • Structure-Activity Relationship
  • Pharmacology & Pharmacy
  • Peripheral Nervous System Diseases
  • Pain
  • Mitogen-Activated Protein Kinases
  • Inflammation
  • Humans
  • Enzyme Inhibitors
  • Enzyme Activation
  • Drug Design