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Central sensitization and LTP: do pain and memory share similar mechanisms?

Publication ,  Journal Article
Ji, R-R; Kohno, T; Moore, KA; Woolf, CJ
Published in: Trends Neurosci
December 2003

Synaptic plasticity is fundamental to many neurobiological functions, including memory and pain. Central sensitization refers to the increased synaptic efficacy established in somatosensory neurons in the dorsal horn of the spinal cord following intense peripheral noxious stimuli, tissue injury or nerve damage. This heightened synaptic transmission leads to a reduction in pain threshold, an amplification of pain responses and a spread of pain sensitivity to non-injured areas. In the cortex, LTP - a long-lasting highly localized increase in synaptic strength - is a synaptic substrate for memory and learning. Analysis of the molecular mechanisms underlying the generation and maintenance of central sensitization and LTP indicates that, although there are differences between the synaptic plasticity contributing to memory and pain, there are also striking similarities.

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Published In

Trends Neurosci

DOI

ISSN

0166-2236

Publication Date

December 2003

Volume

26

Issue

12

Start / End Page

696 / 705

Location

England

Related Subject Headings

  • Sensation
  • Pain
  • Neurology & Neurosurgery
  • Memory
  • Long-Term Potentiation
  • Humans
  • Animals
  • 1702 Cognitive Sciences
  • 1701 Psychology
  • 1109 Neurosciences
 

Citation

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ICMJE
MLA
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Ji, R.-R., Kohno, T., Moore, K. A., & Woolf, C. J. (2003). Central sensitization and LTP: do pain and memory share similar mechanisms? Trends Neurosci, 26(12), 696–705. https://doi.org/10.1016/j.tins.2003.09.017
Ji, Ru-Rong, Tatsuro Kohno, Kimberly A. Moore, and Clifford J. Woolf. “Central sensitization and LTP: do pain and memory share similar mechanisms?Trends Neurosci 26, no. 12 (December 2003): 696–705. https://doi.org/10.1016/j.tins.2003.09.017.
Ji R-R, Kohno T, Moore KA, Woolf CJ. Central sensitization and LTP: do pain and memory share similar mechanisms? Trends Neurosci. 2003 Dec;26(12):696–705.
Ji, Ru-Rong, et al. “Central sensitization and LTP: do pain and memory share similar mechanisms?Trends Neurosci, vol. 26, no. 12, Dec. 2003, pp. 696–705. Pubmed, doi:10.1016/j.tins.2003.09.017.
Ji R-R, Kohno T, Moore KA, Woolf CJ. Central sensitization and LTP: do pain and memory share similar mechanisms? Trends Neurosci. 2003 Dec;26(12):696–705.
Journal cover image

Published In

Trends Neurosci

DOI

ISSN

0166-2236

Publication Date

December 2003

Volume

26

Issue

12

Start / End Page

696 / 705

Location

England

Related Subject Headings

  • Sensation
  • Pain
  • Neurology & Neurosurgery
  • Memory
  • Long-Term Potentiation
  • Humans
  • Animals
  • 1702 Cognitive Sciences
  • 1701 Psychology
  • 1109 Neurosciences