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Removal of GABAergic inhibition facilitates polysynaptic A fiber-mediated excitatory transmission to the superficial spinal dorsal horn.

Publication ,  Journal Article
Baba, H; Ji, R-R; Kohno, T; Moore, KA; Ataka, T; Wakai, A; Okamoto, M; Woolf, CJ
Published in: Mol Cell Neurosci
November 2003

Primary afferent A-fiber stimulation normally evokes fast mono- or polysynaptic EPSCs of short duration. However, in the presence of the GABA(A) receptor antagonist bicuculline, repetitive, long lasting, polysynaptic EPSCs can be observed following the initial, fast response. A-fiber-induced ERK activation is also facilitated in the presence of bicuculline. The frequency of miniature EPSCs and the amplitude of the monosynaptic A-fiber-evoked EPSCs are not affected by bicuculline or the GABA(A) receptor agonist muscimol, suggesting that GABA(A) receptors located on somatodendritic sites of excitatory interneurons are critical for this action. Bicuculline-enhanced polysynaptic EPSCs are completely eliminated by NMDA receptor antagonists APV and ketamine, as was the augmented ERK activation. This NMDA receptor-dependent phenomenon may contribute to bicuculline-induced allodynia or hyperalgesia, as well as the hypersensitivity observed in neuropathic pain patients.

Duke Scholars

Published In

Mol Cell Neurosci

DOI

ISSN

1044-7431

Publication Date

November 2003

Volume

24

Issue

3

Start / End Page

818 / 830

Location

United States

Related Subject Headings

  • gamma-Aminobutyric Acid
  • Synaptic Transmission
  • Synapses
  • Sciatic Neuropathy
  • Receptors, N-Methyl-D-Aspartate
  • Receptors, GABA-A
  • Rats, Sprague-Dawley
  • Rats
  • Posterior Horn Cells
  • Peripheral Nervous System Diseases
 

Citation

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MLA
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Baba, H., Ji, R.-R., Kohno, T., Moore, K. A., Ataka, T., Wakai, A., … Woolf, C. J. (2003). Removal of GABAergic inhibition facilitates polysynaptic A fiber-mediated excitatory transmission to the superficial spinal dorsal horn. Mol Cell Neurosci, 24(3), 818–830. https://doi.org/10.1016/s1044-7431(03)00236-7
Baba, Hiroshi, Ru-Rong Ji, Tatsuro Kohno, Kimberly A. Moore, Toyofumi Ataka, Ayako Wakai, Manabu Okamoto, and Clifford J. Woolf. “Removal of GABAergic inhibition facilitates polysynaptic A fiber-mediated excitatory transmission to the superficial spinal dorsal horn.Mol Cell Neurosci 24, no. 3 (November 2003): 818–30. https://doi.org/10.1016/s1044-7431(03)00236-7.
Baba H, Ji R-R, Kohno T, Moore KA, Ataka T, Wakai A, et al. Removal of GABAergic inhibition facilitates polysynaptic A fiber-mediated excitatory transmission to the superficial spinal dorsal horn. Mol Cell Neurosci. 2003 Nov;24(3):818–30.
Baba, Hiroshi, et al. “Removal of GABAergic inhibition facilitates polysynaptic A fiber-mediated excitatory transmission to the superficial spinal dorsal horn.Mol Cell Neurosci, vol. 24, no. 3, Nov. 2003, pp. 818–30. Pubmed, doi:10.1016/s1044-7431(03)00236-7.
Baba H, Ji R-R, Kohno T, Moore KA, Ataka T, Wakai A, Okamoto M, Woolf CJ. Removal of GABAergic inhibition facilitates polysynaptic A fiber-mediated excitatory transmission to the superficial spinal dorsal horn. Mol Cell Neurosci. 2003 Nov;24(3):818–830.
Journal cover image

Published In

Mol Cell Neurosci

DOI

ISSN

1044-7431

Publication Date

November 2003

Volume

24

Issue

3

Start / End Page

818 / 830

Location

United States

Related Subject Headings

  • gamma-Aminobutyric Acid
  • Synaptic Transmission
  • Synapses
  • Sciatic Neuropathy
  • Receptors, N-Methyl-D-Aspartate
  • Receptors, GABA-A
  • Rats, Sprague-Dawley
  • Rats
  • Posterior Horn Cells
  • Peripheral Nervous System Diseases