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Disruption of ErbB receptor signaling in adult non-myelinating Schwann cells causes progressive sensory loss.

Publication ,  Journal Article
Chen, S; Rio, C; Ji, R-R; Dikkes, P; Coggeshall, RE; Woolf, CJ; Corfas, G
Published in: Nat Neurosci
November 2003

Here we studied the role of signaling through ErbB-family receptors in interactions between unmyelinated axons and non-myelinating Schwann cells in adult nerves. We generated transgenic mice that postnatally express a dominant-negative ErbB receptor in non-myelinating but not in myelinating Schwann cells. These mutant mice present a progressive peripheral neuropathy characterized by extensive Schwann cell proliferation and death, loss of unmyelinated axons and marked heat and cold pain insensitivity. At later stages, C-fiber sensory neurons die by apoptosis, a process that may result from reduced GDNF (glial cell line-derived neurotrophic factor) expression in the sciatic nerve. Neuregulin 1 (NRG1)-ErbB signaling mediates, therefore, reciprocal interactions between non-myelinating Schwann cells and unmyelinated sensory neuron axons that are critical for Schwann cell and C-fiber sensory neuron survival. This study provides new insights into ErbB signaling in adult Schwann cells, the contribution of non-myelinating Schwann cells in maintaining trophic support of sensory neurons, and the possible role of disrupted ErbB signaling in peripheral sensory neuropathies.

Duke Scholars

Published In

Nat Neurosci

DOI

ISSN

1097-6256

Publication Date

November 2003

Volume

6

Issue

11

Start / End Page

1186 / 1193

Location

United States

Related Subject Headings

  • Transcription Factors
  • Trans-Activators
  • Spinal Cord
  • Signal Transduction
  • Sciatic Nerve
  • Schwann Cells
  • Receptors, Purinergic P2X3
  • Receptors, Purinergic P2
  • Receptor, trkA
  • Receptor, ErbB-4
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Chen, S., Rio, C., Ji, R.-R., Dikkes, P., Coggeshall, R. E., Woolf, C. J., & Corfas, G. (2003). Disruption of ErbB receptor signaling in adult non-myelinating Schwann cells causes progressive sensory loss. Nat Neurosci, 6(11), 1186–1193. https://doi.org/10.1038/nn1139
Chen, Suzhen, Carlos Rio, Ru-Rong Ji, Pieter Dikkes, Richard E. Coggeshall, Clifford J. Woolf, and Gabriel Corfas. “Disruption of ErbB receptor signaling in adult non-myelinating Schwann cells causes progressive sensory loss.Nat Neurosci 6, no. 11 (November 2003): 1186–93. https://doi.org/10.1038/nn1139.
Chen S, Rio C, Ji R-R, Dikkes P, Coggeshall RE, Woolf CJ, et al. Disruption of ErbB receptor signaling in adult non-myelinating Schwann cells causes progressive sensory loss. Nat Neurosci. 2003 Nov;6(11):1186–93.
Chen, Suzhen, et al. “Disruption of ErbB receptor signaling in adult non-myelinating Schwann cells causes progressive sensory loss.Nat Neurosci, vol. 6, no. 11, Nov. 2003, pp. 1186–93. Pubmed, doi:10.1038/nn1139.
Chen S, Rio C, Ji R-R, Dikkes P, Coggeshall RE, Woolf CJ, Corfas G. Disruption of ErbB receptor signaling in adult non-myelinating Schwann cells causes progressive sensory loss. Nat Neurosci. 2003 Nov;6(11):1186–1193.

Published In

Nat Neurosci

DOI

ISSN

1097-6256

Publication Date

November 2003

Volume

6

Issue

11

Start / End Page

1186 / 1193

Location

United States

Related Subject Headings

  • Transcription Factors
  • Trans-Activators
  • Spinal Cord
  • Signal Transduction
  • Sciatic Nerve
  • Schwann Cells
  • Receptors, Purinergic P2X3
  • Receptors, Purinergic P2
  • Receptor, trkA
  • Receptor, ErbB-4