Sample size computation for two-sample noninferiority log-rank test.
Publication
, Journal Article
Jung, S-H; Kang, SJ; McCall, LM; Blumenstein, B
Published in: J Biopharm Stat
2005
When an experimental therapy is less extensive, less toxic, or less expensive than a standard therapy, we may want to prove that the former is not worse than the latter through a noninferiority trial. In this article, we discuss a modification of the log-rank test for noninferiority trials with survival endpoint and propose a sample size formula that can be used in designing such trials. Performance of our sample size formula is investigated through simulations. Our formula is applied to design a real clinical trial.
Duke Scholars
Published In
J Biopharm Stat
DOI
ISSN
1054-3406
Publication Date
2005
Volume
15
Issue
6
Start / End Page
969 / 979
Location
England
Related Subject Headings
- Statistics & Probability
- Sample Size
- Models, Statistical
- Data Interpretation, Statistical
- Computer Simulation
- Clinical Trials as Topic
- 4905 Statistics
- 3214 Pharmacology and pharmaceutical sciences
- 1115 Pharmacology and Pharmaceutical Sciences
Citation
APA
Chicago
ICMJE
MLA
NLM
Jung, S.-H., Kang, S. J., McCall, L. M., & Blumenstein, B. (2005). Sample size computation for two-sample noninferiority log-rank test. J Biopharm Stat, 15(6), 969–979. https://doi.org/10.1080/10543400500265736
Jung, Sin-Ho, Sun J. Kang, Linda M. McCall, and Brent Blumenstein. “Sample size computation for two-sample noninferiority log-rank test.” J Biopharm Stat 15, no. 6 (2005): 969–79. https://doi.org/10.1080/10543400500265736.
Jung S-H, Kang SJ, McCall LM, Blumenstein B. Sample size computation for two-sample noninferiority log-rank test. J Biopharm Stat. 2005;15(6):969–79.
Jung, Sin-Ho, et al. “Sample size computation for two-sample noninferiority log-rank test.” J Biopharm Stat, vol. 15, no. 6, 2005, pp. 969–79. Pubmed, doi:10.1080/10543400500265736.
Jung S-H, Kang SJ, McCall LM, Blumenstein B. Sample size computation for two-sample noninferiority log-rank test. J Biopharm Stat. 2005;15(6):969–979.
Published In
J Biopharm Stat
DOI
ISSN
1054-3406
Publication Date
2005
Volume
15
Issue
6
Start / End Page
969 / 979
Location
England
Related Subject Headings
- Statistics & Probability
- Sample Size
- Models, Statistical
- Data Interpretation, Statistical
- Computer Simulation
- Clinical Trials as Topic
- 4905 Statistics
- 3214 Pharmacology and pharmaceutical sciences
- 1115 Pharmacology and Pharmaceutical Sciences