A parametric model for long-term follow-up data from phase III breast cancer clinical trials.
Publication
, Journal Article
Jeong, J-H; Jung, S-H; Wieand, S
Published in: Stat Med
February 15, 2003
We propose a parametric version of a univariate gamma frailty model. The proposed model is shown to be flexible enough to model long-term follow-up survival data from breast cancer clinical trials when the treatment effect diminishes as time progresses, a case for which neither the proportional hazards nor proportional odds assumptions are satisfied. The observed information matrix is computed to evaluate the variances of parameter estimates. A simple parametric test statistic to test proportional odds assumption is also constructed. The model is applied to a data set from a phase III clinical trial on breast cancer.
Duke Scholars
Published In
Stat Med
DOI
ISSN
0277-6715
Publication Date
February 15, 2003
Volume
22
Issue
3
Start / End Page
339 / 352
Location
England
Related Subject Headings
- Tamoxifen
- Statistics & Probability
- Models, Statistical
- Humans
- Follow-Up Studies
- Female
- Disease-Free Survival
- Data Interpretation, Statistical
- Computer Simulation
- Clinical Trials, Phase III as Topic
Citation
APA
Chicago
ICMJE
MLA
NLM
Jeong, J.-H., Jung, S.-H., & Wieand, S. (2003). A parametric model for long-term follow-up data from phase III breast cancer clinical trials. Stat Med, 22(3), 339–352. https://doi.org/10.1002/sim.1349
Jeong, Jong-Hyeon, Sin-Ho Jung, and Samuel Wieand. “A parametric model for long-term follow-up data from phase III breast cancer clinical trials.” Stat Med 22, no. 3 (February 15, 2003): 339–52. https://doi.org/10.1002/sim.1349.
Jeong J-H, Jung S-H, Wieand S. A parametric model for long-term follow-up data from phase III breast cancer clinical trials. Stat Med. 2003 Feb 15;22(3):339–52.
Jeong, Jong-Hyeon, et al. “A parametric model for long-term follow-up data from phase III breast cancer clinical trials.” Stat Med, vol. 22, no. 3, Feb. 2003, pp. 339–52. Pubmed, doi:10.1002/sim.1349.
Jeong J-H, Jung S-H, Wieand S. A parametric model for long-term follow-up data from phase III breast cancer clinical trials. Stat Med. 2003 Feb 15;22(3):339–352.
Published In
Stat Med
DOI
ISSN
0277-6715
Publication Date
February 15, 2003
Volume
22
Issue
3
Start / End Page
339 / 352
Location
England
Related Subject Headings
- Tamoxifen
- Statistics & Probability
- Models, Statistical
- Humans
- Follow-Up Studies
- Female
- Disease-Free Survival
- Data Interpretation, Statistical
- Computer Simulation
- Clinical Trials, Phase III as Topic