Cell-cycle checkpoints and cancer.
Publication
, Journal Article
Kastan, MB; Bartek, J
Published in: Nature
November 18, 2004
All life on earth must cope with constant exposure to DNA-damaging agents such as the Sun's radiation. Highly conserved DNA-repair and cell-cycle checkpoint pathways allow cells to deal with both endogenous and exogenous sources of DNA damage. How much an individual is exposed to these agents and how their cells respond to DNA damage are critical determinants of whether that individual will develop cancer. These cellular responses are also important for determining toxicities and responses to current cancer therapies, most of which target the DNA.
Duke Scholars
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Published In
Nature
DOI
EISSN
1476-4687
Publication Date
November 18, 2004
Volume
432
Issue
7015
Start / End Page
316 / 323
Location
England
Related Subject Headings
- Signal Transduction
- Neoplasms
- Humans
- General Science & Technology
- DNA Damage
- Cell Cycle
- Animals
Citation
APA
Chicago
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MLA
NLM
Kastan, M. B., & Bartek, J. (2004). Cell-cycle checkpoints and cancer. Nature, 432(7015), 316–323. https://doi.org/10.1038/nature03097
Kastan, Michael B., and Jiri Bartek. “Cell-cycle checkpoints and cancer.” Nature 432, no. 7015 (November 18, 2004): 316–23. https://doi.org/10.1038/nature03097.
Kastan MB, Bartek J. Cell-cycle checkpoints and cancer. Nature. 2004 Nov 18;432(7015):316–23.
Kastan, Michael B., and Jiri Bartek. “Cell-cycle checkpoints and cancer.” Nature, vol. 432, no. 7015, Nov. 2004, pp. 316–23. Pubmed, doi:10.1038/nature03097.
Kastan MB, Bartek J. Cell-cycle checkpoints and cancer. Nature. 2004 Nov 18;432(7015):316–323.
Published In
Nature
DOI
EISSN
1476-4687
Publication Date
November 18, 2004
Volume
432
Issue
7015
Start / End Page
316 / 323
Location
England
Related Subject Headings
- Signal Transduction
- Neoplasms
- Humans
- General Science & Technology
- DNA Damage
- Cell Cycle
- Animals