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p53 and ATM: cell cycle, cell death, and cancer.

Publication ,  Journal Article
Morgan, SE; Kastan, MB
Published in: Adv Cancer Res
1997

The development of a normal cell into a tumor cell appears to depend in part on mutations in genes that normally control cell cycle and cell death, thereby resulting in inappropriate cellular survival and tumorigenesis. ATM ("mutated in ataxia-telangiectasia") and p53 are two gene products that are believed to play a major role in maintaining the integrity of the genome such that alterations in these gene products may contribute to increased incidence of genomic changes such as deletions, translocations, and amplifications, which are common during oncogenesis. p53 is a critical participant in a signal transduction pathway that mediates either a G1 arrest or apoptosis in response to DNA damage. In addition, p53 is believed to be involved in the mitotic spindle checkpoint and in the regulation of centrosome function. Following certain cytotoxic stresses, normal ATM function is required for p53-mediated G1 arrest. ATM is also involved in other cellular processes such as S phase and G2-M phase arrest and in radiosensitivity. The understanding of the roles that both p53 and ATM play in cell cycle progression and cell death in response to DNA damage may provide new insights into the molecular mechanisms of cellular transformation and may help identify potential targets for improved cancer therapies.

Duke Scholars

Published In

Adv Cancer Res

DOI

ISSN

0065-230X

Publication Date

1997

Volume

71

Start / End Page

1 / 25

Location

United States

Related Subject Headings

  • Tumor Suppressor Proteins
  • Tumor Suppressor Protein p53
  • Signal Transduction
  • Proteins
  • Protein Serine-Threonine Kinases
  • Phosphotransferases (Alcohol Group Acceptor)
  • Phosphatidylinositol 3-Kinases
  • Oncology & Carcinogenesis
  • Neoplasms
  • Humans
 

Citation

APA
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MLA
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Morgan, S. E., & Kastan, M. B. (1997). p53 and ATM: cell cycle, cell death, and cancer. Adv Cancer Res, 71, 1–25. https://doi.org/10.1016/s0065-230x(08)60095-0
Morgan, S. E., and M. B. Kastan. “p53 and ATM: cell cycle, cell death, and cancer.Adv Cancer Res 71 (1997): 1–25. https://doi.org/10.1016/s0065-230x(08)60095-0.
Morgan SE, Kastan MB. p53 and ATM: cell cycle, cell death, and cancer. Adv Cancer Res. 1997;71:1–25.
Morgan, S. E., and M. B. Kastan. “p53 and ATM: cell cycle, cell death, and cancer.Adv Cancer Res, vol. 71, 1997, pp. 1–25. Pubmed, doi:10.1016/s0065-230x(08)60095-0.
Morgan SE, Kastan MB. p53 and ATM: cell cycle, cell death, and cancer. Adv Cancer Res. 1997;71:1–25.
Journal cover image

Published In

Adv Cancer Res

DOI

ISSN

0065-230X

Publication Date

1997

Volume

71

Start / End Page

1 / 25

Location

United States

Related Subject Headings

  • Tumor Suppressor Proteins
  • Tumor Suppressor Protein p53
  • Signal Transduction
  • Proteins
  • Protein Serine-Threonine Kinases
  • Phosphotransferases (Alcohol Group Acceptor)
  • Phosphatidylinositol 3-Kinases
  • Oncology & Carcinogenesis
  • Neoplasms
  • Humans