
Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen.
Publication
, Journal Article
Smith, ML; Chen, IT; Zhan, Q; Bae, I; Chen, CY; Gilmer, TM; Kastan, MB; O'Connor, PM; Fornace, AJ
Published in: Science
November 25, 1994
GADD45 is a ubiquitously expressed mammalian gene that is induced by DNA damage and certain other stresses. Like another p53-regulated gene, p21WAF1/CIP1, whose product binds to cyclin-dependent kinases (Cdk's) and proliferating cell nuclear antigen (PCNA), GADD45 has been associated with growth suppression. Gadd45 was found to bind to PCNA, a normal component of Cdk complexes and a protein involved in DNA replication and repair. Gadd45 stimulated DNA excision repair in vitro and inhibited entry of cells into S phase. These results establish GADD45 as a link between the p53-dependent cell cycle checkpoint and DNA repair.
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Published In
Science
DOI
ISSN
0036-8075
Publication Date
November 25, 1994
Volume
266
Issue
5189
Start / End Page
1376 / 1380
Location
United States
Related Subject Headings
- Tumor Cells, Cultured
- Transfection
- S Phase
- Recombinant Proteins
- Proteins
- Proliferating Cell Nuclear Antigen
- Intracellular Signaling Peptides and Proteins
- Humans
- Genes, p53
- General Science & Technology
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APA
Chicago
ICMJE
MLA
NLM
Smith, M. L., Chen, I. T., Zhan, Q., Bae, I., Chen, C. Y., Gilmer, T. M., … Fornace, A. J. (1994). Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen. Science, 266(5189), 1376–1380. https://doi.org/10.1126/science.7973727
Smith, M. L., I. T. Chen, Q. Zhan, I. Bae, C. Y. Chen, T. M. Gilmer, M. B. Kastan, P. M. O’Connor, and A. J. Fornace. “Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen.” Science 266, no. 5189 (November 25, 1994): 1376–80. https://doi.org/10.1126/science.7973727.
Smith ML, Chen IT, Zhan Q, Bae I, Chen CY, Gilmer TM, et al. Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen. Science. 1994 Nov 25;266(5189):1376–80.
Smith, M. L., et al. “Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen.” Science, vol. 266, no. 5189, Nov. 1994, pp. 1376–80. Pubmed, doi:10.1126/science.7973727.
Smith ML, Chen IT, Zhan Q, Bae I, Chen CY, Gilmer TM, Kastan MB, O’Connor PM, Fornace AJ. Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen. Science. 1994 Nov 25;266(5189):1376–1380.

Published In
Science
DOI
ISSN
0036-8075
Publication Date
November 25, 1994
Volume
266
Issue
5189
Start / End Page
1376 / 1380
Location
United States
Related Subject Headings
- Tumor Cells, Cultured
- Transfection
- S Phase
- Recombinant Proteins
- Proteins
- Proliferating Cell Nuclear Antigen
- Intracellular Signaling Peptides and Proteins
- Humans
- Genes, p53
- General Science & Technology