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Cell cycle control and cancer.

Publication ,  Journal Article
Hartwell, LH; Kastan, MB
Published in: Science
December 16, 1994

Multiple genetic changes occur during the evolution of normal cells into cancer cells. This evolution is facilitated in cancer cells by loss of fidelity in the processes that replicate, repair, and segregate the genome. Recent advances in our understanding of the cell cycle reveal how fidelity is normally achieved by the coordinated activity of cyclin-dependent kinases, checkpoint controls, and repair pathways and how this fidelity can be abrogated by specific genetic changes. These insights suggest molecular mechanisms for cellular transformation and may help to identify potential targets for improved cancer therapies.

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Published In

Science

DOI

ISSN

0036-8075

Publication Date

December 16, 1994

Volume

266

Issue

5192

Start / End Page

1821 / 1828

Location

United States

Related Subject Headings

  • Tumor Suppressor Protein p53
  • Signal Transduction
  • Neoplasms
  • Humans
  • General Science & Technology
  • DNA Damage
  • Cyclins
  • Cellular Senescence
  • Cell Transformation, Neoplastic
  • Cell Cycle
 

Citation

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Hartwell, L. H., & Kastan, M. B. (1994). Cell cycle control and cancer. Science, 266(5192), 1821–1828. https://doi.org/10.1126/science.7997877
Hartwell, L. H., and M. B. Kastan. “Cell cycle control and cancer.Science 266, no. 5192 (December 16, 1994): 1821–28. https://doi.org/10.1126/science.7997877.
Hartwell LH, Kastan MB. Cell cycle control and cancer. Science. 1994 Dec 16;266(5192):1821–8.
Hartwell, L. H., and M. B. Kastan. “Cell cycle control and cancer.Science, vol. 266, no. 5192, Dec. 1994, pp. 1821–28. Pubmed, doi:10.1126/science.7997877.
Hartwell LH, Kastan MB. Cell cycle control and cancer. Science. 1994 Dec 16;266(5192):1821–1828.
Journal cover image

Published In

Science

DOI

ISSN

0036-8075

Publication Date

December 16, 1994

Volume

266

Issue

5192

Start / End Page

1821 / 1828

Location

United States

Related Subject Headings

  • Tumor Suppressor Protein p53
  • Signal Transduction
  • Neoplasms
  • Humans
  • General Science & Technology
  • DNA Damage
  • Cyclins
  • Cellular Senescence
  • Cell Transformation, Neoplastic
  • Cell Cycle