
Cell cycle control and cancer.
Publication
, Journal Article
Hartwell, LH; Kastan, MB
Published in: Science
December 16, 1994
Multiple genetic changes occur during the evolution of normal cells into cancer cells. This evolution is facilitated in cancer cells by loss of fidelity in the processes that replicate, repair, and segregate the genome. Recent advances in our understanding of the cell cycle reveal how fidelity is normally achieved by the coordinated activity of cyclin-dependent kinases, checkpoint controls, and repair pathways and how this fidelity can be abrogated by specific genetic changes. These insights suggest molecular mechanisms for cellular transformation and may help to identify potential targets for improved cancer therapies.
Duke Scholars
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Published In
Science
DOI
ISSN
0036-8075
Publication Date
December 16, 1994
Volume
266
Issue
5192
Start / End Page
1821 / 1828
Location
United States
Related Subject Headings
- Tumor Suppressor Protein p53
- Signal Transduction
- Neoplasms
- Humans
- General Science & Technology
- DNA Damage
- Cyclins
- Cellular Senescence
- Cell Transformation, Neoplastic
- Cell Cycle
Citation
APA
Chicago
ICMJE
MLA
NLM
Hartwell, L. H., & Kastan, M. B. (1994). Cell cycle control and cancer. Science, 266(5192), 1821–1828. https://doi.org/10.1126/science.7997877
Hartwell, L. H., and M. B. Kastan. “Cell cycle control and cancer.” Science 266, no. 5192 (December 16, 1994): 1821–28. https://doi.org/10.1126/science.7997877.
Hartwell LH, Kastan MB. Cell cycle control and cancer. Science. 1994 Dec 16;266(5192):1821–8.
Hartwell, L. H., and M. B. Kastan. “Cell cycle control and cancer.” Science, vol. 266, no. 5192, Dec. 1994, pp. 1821–28. Pubmed, doi:10.1126/science.7997877.
Hartwell LH, Kastan MB. Cell cycle control and cancer. Science. 1994 Dec 16;266(5192):1821–1828.

Published In
Science
DOI
ISSN
0036-8075
Publication Date
December 16, 1994
Volume
266
Issue
5192
Start / End Page
1821 / 1828
Location
United States
Related Subject Headings
- Tumor Suppressor Protein p53
- Signal Transduction
- Neoplasms
- Humans
- General Science & Technology
- DNA Damage
- Cyclins
- Cellular Senescence
- Cell Transformation, Neoplastic
- Cell Cycle