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Acute neurotoxicity after intrathecal cytosine arabinoside in two adolescents with acute lymphoblastic leukemia of B-cell type.

Publication ,  Journal Article
Resar, LM; Phillips, PC; Kastan, MB; Leventhal, BG; Bowman, PW; Civin, CI
Published in: Cancer
January 1, 1993

BACKGROUND: Two adolescents with acute B-cell leukemia (Burkitt leukemia) had acute severe neurotoxicity after treatment with intrathecal (IT) cytosine arabinoside (AraC) at a dose of 50 mg/day for three consecutive days. RESULTS: A 16-year-old boy had a rapidly ascending myelopathy and encephalopathy 20 hours after receiving the third dose of IT AraC. He remained quadriplegic and required ventilatory assistance for 10 months until his death from progressive tumor. A 12-year-old girl had acute encephalopathy, seizures, and focal neuroimaging abnormalities in the cerebellum and brain stem within 32 hours of the third AraC dose and 8 hours after IT methotrexate (MTX, 12 mg). Her clinical neurologic deficits resolved during the ensuing month. Patient 1 represents the first report to the authors' knowledge of acute severe neurotoxicity after AraC administered as the only IT drug. In Patient 2, IT AraC neurotoxicity may have been potentiated by the single dose of MTX. CONCLUSION: IT AraC administered for 3 or more consecutive days may lead to profound neurologic dysfunction and require discontinuation of therapy.

Duke Scholars

Published In

Cancer

DOI

ISSN

0008-543X

Publication Date

January 1, 1993

Volume

71

Issue

1

Start / End Page

117 / 123

Location

United States

Related Subject Headings

  • Tomography, X-Ray Computed
  • Spinal Cord Diseases
  • Oncology & Carcinogenesis
  • Neurologic Examination
  • Male
  • Injections, Spinal
  • Humans
  • Female
  • Cytarabine
  • Child
 

Citation

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MLA
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Resar, L. M., Phillips, P. C., Kastan, M. B., Leventhal, B. G., Bowman, P. W., & Civin, C. I. (1993). Acute neurotoxicity after intrathecal cytosine arabinoside in two adolescents with acute lymphoblastic leukemia of B-cell type. Cancer, 71(1), 117–123. https://doi.org/10.1002/1097-0142(19930101)71:1<117::aid-cncr2820710119>3.0.co;2-k
Resar, L. M., P. C. Phillips, M. B. Kastan, B. G. Leventhal, P. W. Bowman, and C. I. Civin. “Acute neurotoxicity after intrathecal cytosine arabinoside in two adolescents with acute lymphoblastic leukemia of B-cell type.Cancer 71, no. 1 (January 1, 1993): 117–23. https://doi.org/10.1002/1097-0142(19930101)71:1<117::aid-cncr2820710119>3.0.co;2-k.
Resar LM, Phillips PC, Kastan MB, Leventhal BG, Bowman PW, Civin CI. Acute neurotoxicity after intrathecal cytosine arabinoside in two adolescents with acute lymphoblastic leukemia of B-cell type. Cancer. 1993 Jan 1;71(1):117–23.
Resar, L. M., et al. “Acute neurotoxicity after intrathecal cytosine arabinoside in two adolescents with acute lymphoblastic leukemia of B-cell type.Cancer, vol. 71, no. 1, Jan. 1993, pp. 117–23. Pubmed, doi:10.1002/1097-0142(19930101)71:1<117::aid-cncr2820710119>3.0.co;2-k.
Resar LM, Phillips PC, Kastan MB, Leventhal BG, Bowman PW, Civin CI. Acute neurotoxicity after intrathecal cytosine arabinoside in two adolescents with acute lymphoblastic leukemia of B-cell type. Cancer. 1993 Jan 1;71(1):117–123.
Journal cover image

Published In

Cancer

DOI

ISSN

0008-543X

Publication Date

January 1, 1993

Volume

71

Issue

1

Start / End Page

117 / 123

Location

United States

Related Subject Headings

  • Tomography, X-Ray Computed
  • Spinal Cord Diseases
  • Oncology & Carcinogenesis
  • Neurologic Examination
  • Male
  • Injections, Spinal
  • Humans
  • Female
  • Cytarabine
  • Child