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Hierarchical temporal processing deficit model of reality distortion and psychoses.

Publication ,  Journal Article
Krishnan, RR; Fivaz, M; Kraus, MS; Keefe, RSE
Published in: Mol Psychiatry
February 2011

We posit in this article that hierarchical temporal processing deficit is the underlying basis of reality distortion and psychoses. Schizophrenia is a prototypical reality distortion disorder in which the patient manifests with auditory hallucinations, delusions, disorganized speech and thinking, cognitive impairment, avolition and social and occupational dysfunction. Reality distortion can be present in many other disorders including bipolar disorder, major depression and even dementia. Conceptually, schizophrenia is a heterogeneous entity likely to be because of numerous causes similar to dementia. Although no single symptom or set of symptoms is pathognomonic, a cardinal feature in all patients with schizophrenia is chronic distortion of reality. The model that we have proposed accounts for the varied manifestations of reality distortion including hallucinations and delusions. In this paper we consider the implications of this model for the underlying biology of psychoses and also for the neurobiology of schizophrenia and suggest potential targets to consider for the etiology and pathophysiology of reality distortion, especially in the context of schizophrenia.

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Published In

Mol Psychiatry

DOI

EISSN

1476-5578

Publication Date

February 2011

Volume

16

Issue

2

Start / End Page

129 / 144

Location

England

Related Subject Headings

  • Schizophrenic Psychology
  • Schizophrenia
  • Reality Testing
  • Psychotic Disorders
  • Psychiatry
  • Perceptual Disorders
  • Models, Psychological
  • Models, Neurological
  • Humans
  • Cognition Disorders
 

Citation

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Krishnan, R. R., Fivaz, M., Kraus, M. S., & Keefe, R. S. E. (2011). Hierarchical temporal processing deficit model of reality distortion and psychoses. Mol Psychiatry, 16(2), 129–144. https://doi.org/10.1038/mp.2010.63
Krishnan, R. R., M. Fivaz, M. S. Kraus, and R. S. E. Keefe. “Hierarchical temporal processing deficit model of reality distortion and psychoses.Mol Psychiatry 16, no. 2 (February 2011): 129–44. https://doi.org/10.1038/mp.2010.63.
Krishnan RR, Fivaz M, Kraus MS, Keefe RSE. Hierarchical temporal processing deficit model of reality distortion and psychoses. Mol Psychiatry. 2011 Feb;16(2):129–44.
Krishnan, R. R., et al. “Hierarchical temporal processing deficit model of reality distortion and psychoses.Mol Psychiatry, vol. 16, no. 2, Feb. 2011, pp. 129–44. Pubmed, doi:10.1038/mp.2010.63.
Krishnan RR, Fivaz M, Kraus MS, Keefe RSE. Hierarchical temporal processing deficit model of reality distortion and psychoses. Mol Psychiatry. 2011 Feb;16(2):129–144.

Published In

Mol Psychiatry

DOI

EISSN

1476-5578

Publication Date

February 2011

Volume

16

Issue

2

Start / End Page

129 / 144

Location

England

Related Subject Headings

  • Schizophrenic Psychology
  • Schizophrenia
  • Reality Testing
  • Psychotic Disorders
  • Psychiatry
  • Perceptual Disorders
  • Models, Psychological
  • Models, Neurological
  • Humans
  • Cognition Disorders