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RNA regulons: coordination of post-transcriptional events.

Publication ,  Journal Article
Keene, JD
Published in: Nat Rev Genet
July 2007

Recent findings demonstrate that multiple mRNAs are co-regulated by one or more sequence-specific RNA-binding proteins that orchestrate their splicing, export, stability, localization and translation. These and other observations have given rise to a model in which mRNAs that encode functionally related proteins are coordinately regulated during cell growth and differentiation as post-transcriptional RNA operons or regulons, through a ribonucleoprotein-driven mechanism. Here I describe several recently discovered examples of RNA operons in budding yeast, fruitfly and mammalian cells, and their potential importance in processes such as immune response, oxidative metabolism, stress response, circadian rhythms and disease. I close by considering the evolutionary wiring and rewiring of these combinatorial post-transcriptional gene-expression networks.

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Published In

Nat Rev Genet

DOI

ISSN

1471-0056

Publication Date

July 2007

Volume

8

Issue

7

Start / End Page

533 / 543

Location

England

Related Subject Headings

  • Transcription, Genetic
  • Saccharomycetales
  • Regulon
  • RNA-Binding Proteins
  • RNA Splicing
  • RNA Processing, Post-Transcriptional
  • RNA
  • Protein Biosynthesis
  • Operon
  • Models, Genetic
 

Citation

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Keene, J. D. (2007). RNA regulons: coordination of post-transcriptional events. Nat Rev Genet, 8(7), 533–543. https://doi.org/10.1038/nrg2111
Keene, Jack D. “RNA regulons: coordination of post-transcriptional events.Nat Rev Genet 8, no. 7 (July 2007): 533–43. https://doi.org/10.1038/nrg2111.
Keene JD. RNA regulons: coordination of post-transcriptional events. Nat Rev Genet. 2007 Jul;8(7):533–43.
Keene, Jack D. “RNA regulons: coordination of post-transcriptional events.Nat Rev Genet, vol. 8, no. 7, July 2007, pp. 533–43. Pubmed, doi:10.1038/nrg2111.
Keene JD. RNA regulons: coordination of post-transcriptional events. Nat Rev Genet. 2007 Jul;8(7):533–543.

Published In

Nat Rev Genet

DOI

ISSN

1471-0056

Publication Date

July 2007

Volume

8

Issue

7

Start / End Page

533 / 543

Location

England

Related Subject Headings

  • Transcription, Genetic
  • Saccharomycetales
  • Regulon
  • RNA-Binding Proteins
  • RNA Splicing
  • RNA Processing, Post-Transcriptional
  • RNA
  • Protein Biosynthesis
  • Operon
  • Models, Genetic