Eukaryotic mRNPs may represent posttranscriptional operons.
Publication
, Journal Article
Keene, JD; Tenenbaum, SA
Published in: Mol Cell
June 2002
Genomic array analysis of endogenous mammalian ribonucleoproteins has recently revealed three novel findings: (1) mRNA binding proteins are associated with unique subpopulations of messages, (2) the compositions of these mRNA subsets can vary with growth conditions, and (3) the same mRNA species can be found in multiple mRNP complexes. Based on these and other findings, we propose a model of posttranscriptional gene expression in which mRNA binding proteins regulate mRNAs as subpopulations during cell growth and development. This model predicts that functionally related genes are regulated posttranscriptionally as groups by specific mRNA binding proteins that recognize sequence elements in common among the mRNAs.
Duke Scholars
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Published In
Mol Cell
DOI
ISSN
1097-2765
Publication Date
June 2002
Volume
9
Issue
6
Start / End Page
1161 / 1167
Location
United States
Related Subject Headings
- Ribonucleoproteins
- Regulatory Sequences, Nucleic Acid
- RNA-Binding Proteins
- RNA, Messenger
- Operon
- Models, Genetic
- Gene Expression Regulation
- Developmental Biology
- Animals
- 11 Medical and Health Sciences
Citation
APA
Chicago
ICMJE
MLA
NLM
Keene, J. D., & Tenenbaum, S. A. (2002). Eukaryotic mRNPs may represent posttranscriptional operons. Mol Cell, 9(6), 1161–1167. https://doi.org/10.1016/s1097-2765(02)00559-2
Keene, Jack D., and Scott A. Tenenbaum. “Eukaryotic mRNPs may represent posttranscriptional operons.” Mol Cell 9, no. 6 (June 2002): 1161–67. https://doi.org/10.1016/s1097-2765(02)00559-2.
Keene JD, Tenenbaum SA. Eukaryotic mRNPs may represent posttranscriptional operons. Mol Cell. 2002 Jun;9(6):1161–7.
Keene, Jack D., and Scott A. Tenenbaum. “Eukaryotic mRNPs may represent posttranscriptional operons.” Mol Cell, vol. 9, no. 6, June 2002, pp. 1161–67. Pubmed, doi:10.1016/s1097-2765(02)00559-2.
Keene JD, Tenenbaum SA. Eukaryotic mRNPs may represent posttranscriptional operons. Mol Cell. 2002 Jun;9(6):1161–1167.
Published In
Mol Cell
DOI
ISSN
1097-2765
Publication Date
June 2002
Volume
9
Issue
6
Start / End Page
1161 / 1167
Location
United States
Related Subject Headings
- Ribonucleoproteins
- Regulatory Sequences, Nucleic Acid
- RNA-Binding Proteins
- RNA, Messenger
- Operon
- Models, Genetic
- Gene Expression Regulation
- Developmental Biology
- Animals
- 11 Medical and Health Sciences