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Topical microbicides: the time has come.

Publication ,  Journal Article
Dhawan, D; Keller, M; Klotman, ME
Published in: AIDS Read
March 2006

Microbicides are vaginally or rectally applied drugs that inhibit HIV and other sexually transmitted pathogens. About 30 microbicidal products are being studied in preclinical and clinical trials. Data from in vitro, animal, and in vivo investigations with candidate microbicidal compounds support a proof of concept, although large-scale clinical trials will determine efficacy. Because there are multiple targets for HIV infection in the genital tract, synergistic combinations of microbicides will probably offer the greatest protection for non-HIV-infected persons and might decrease transmissibility when used by those infected with HIV.

Duke Scholars

Published In

AIDS Read

ISSN

1053-0894

Publication Date

March 2006

Volume

16

Issue

3

Start / End Page

144 / 161

Location

United States

Related Subject Headings

  • Virology
  • Sexually Transmitted Diseases
  • Rabbits
  • Male
  • Macaca
  • Humans
  • HIV Infections
  • Female
  • Clinical Trials as Topic
  • Anti-Infective Agents, Local
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Dhawan, D., Keller, M., & Klotman, M. E. (2006). Topical microbicides: the time has come. AIDS Read, 16(3), 144–161.
Dhawan, Darpun, Marla Keller, and Mary E. Klotman. “Topical microbicides: the time has come.AIDS Read 16, no. 3 (March 2006): 144–61.
Dhawan D, Keller M, Klotman ME. Topical microbicides: the time has come. AIDS Read. 2006 Mar;16(3):144–61.
Dhawan, Darpun, et al. “Topical microbicides: the time has come.AIDS Read, vol. 16, no. 3, Mar. 2006, pp. 144–61.
Dhawan D, Keller M, Klotman ME. Topical microbicides: the time has come. AIDS Read. 2006 Mar;16(3):144–161.

Published In

AIDS Read

ISSN

1053-0894

Publication Date

March 2006

Volume

16

Issue

3

Start / End Page

144 / 161

Location

United States

Related Subject Headings

  • Virology
  • Sexually Transmitted Diseases
  • Rabbits
  • Male
  • Macaca
  • Humans
  • HIV Infections
  • Female
  • Clinical Trials as Topic
  • Anti-Infective Agents, Local