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Severe obesity is associated with symptomatic presentation, higher parathyroid hormone levels, and increased gland weight in primary hyperparathyroidism.

Publication ,  Journal Article
Adam, MA; Untch, BR; Danko, ME; Stinnett, S; Dixit, D; Koh, J; Marks, JR; Olson, JA
Published in: J Clin Endocrinol Metab
November 2010

CONTEXT: A relationship between primary hyperparathyroidism (PHPT) and obesity has been observed but is incompletely understood. Furthermore, obesity has been associated with vitamin D deficiency, suggesting that the three conditions may be linked. OBJECTIVE: We hypothesized that PHPT in morbidly obese patients is more severe and that the difference may be explained by vitamin D deficiency. DESIGN AND SETTING, PARTICIPANTS, AND OUTCOME MEASURES: Records of 196 patients with surgically treated PHPT and known body mass index (BMI) were examined. Patients were stratified into three BMI groups: group I (nonobese), BMI < 25 kg/m(2) (n = 54); group II (non-severely obese), BMI 25-34 kg/m(2) (n = 102); and group III (severely obese), BMI 35 kg/m(2) or greater (n = 40). RESULTS: Preoperative PTH levels were higher in group ΙΙΙ compared with group Ι (181 ± 153 vs. 140 ± 80 pg/ml, p = 0.04). Group III patients had larger tumors on average compared with group I (1.8 ± 1.5 vs. 1.04 ± 1.5 g, P = 0.0002). In group III, BMI positively correlated with parathyroid tumor weight (r = 0.5, P = 0.002). Postoperative PTH was higher in group III compared with group Ι (61 ± 41 vs. 44 ± 28 pg/ml, P = 0.02). There was higher frequency of depression, musculoskeletal symptoms, weakness, and gastroesophageal reflux disease in group III patients. CONCLUSIONS: BMI positively correlated with parathyroid tumor weight independent of vitamin D. Severely obese patients have larger parathyroid tumor weight, higher pre- and postoperative PTH, and greater symptoms.

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Published In

J Clin Endocrinol Metab

DOI

EISSN

1945-7197

Publication Date

November 2010

Volume

95

Issue

11

Start / End Page

4917 / 4924

Location

United States

Related Subject Headings

  • Vitamin D Deficiency
  • Vitamin D
  • Severity of Illness Index
  • Parathyroid Neoplasms
  • Parathyroid Hormone
  • Parathyroid Glands
  • Obesity
  • Medical Records
  • Hyperparathyroidism
  • Humans
 

Citation

APA
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ICMJE
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Adam, M. A., Untch, B. R., Danko, M. E., Stinnett, S., Dixit, D., Koh, J., … Olson, J. A. (2010). Severe obesity is associated with symptomatic presentation, higher parathyroid hormone levels, and increased gland weight in primary hyperparathyroidism. J Clin Endocrinol Metab, 95(11), 4917–4924. https://doi.org/10.1210/jc.2010-0666
Adam, Mohamed Abdelgadir, Brian R. Untch, Melissa E. Danko, Sandra Stinnett, Darshana Dixit, James Koh, Jeffrey R. Marks, and John A. Olson. “Severe obesity is associated with symptomatic presentation, higher parathyroid hormone levels, and increased gland weight in primary hyperparathyroidism.J Clin Endocrinol Metab 95, no. 11 (November 2010): 4917–24. https://doi.org/10.1210/jc.2010-0666.
Adam MA, Untch BR, Danko ME, Stinnett S, Dixit D, Koh J, et al. Severe obesity is associated with symptomatic presentation, higher parathyroid hormone levels, and increased gland weight in primary hyperparathyroidism. J Clin Endocrinol Metab. 2010 Nov;95(11):4917–24.
Adam, Mohamed Abdelgadir, et al. “Severe obesity is associated with symptomatic presentation, higher parathyroid hormone levels, and increased gland weight in primary hyperparathyroidism.J Clin Endocrinol Metab, vol. 95, no. 11, Nov. 2010, pp. 4917–24. Pubmed, doi:10.1210/jc.2010-0666.
Adam MA, Untch BR, Danko ME, Stinnett S, Dixit D, Koh J, Marks JR, Olson JA. Severe obesity is associated with symptomatic presentation, higher parathyroid hormone levels, and increased gland weight in primary hyperparathyroidism. J Clin Endocrinol Metab. 2010 Nov;95(11):4917–4924.
Journal cover image

Published In

J Clin Endocrinol Metab

DOI

EISSN

1945-7197

Publication Date

November 2010

Volume

95

Issue

11

Start / End Page

4917 / 4924

Location

United States

Related Subject Headings

  • Vitamin D Deficiency
  • Vitamin D
  • Severity of Illness Index
  • Parathyroid Neoplasms
  • Parathyroid Hormone
  • Parathyroid Glands
  • Obesity
  • Medical Records
  • Hyperparathyroidism
  • Humans