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Treatment of posttraumatic stress disorder with amitriptyline and placebo.

Publication ,  Journal Article
Davidson, J; Kudler, H; Smith, R; Mahorney, SL; Lipper, S; Hammett, E; Saunders, WB; Cavenar, JO
Published in: Arch Gen Psychiatry
March 1990

Amitriptyline hydrochloride was compared with placebo in 46 veterans with chronic posttraumatic stress disorder. Treatment continued up to 8 weeks, and efficacy was measured by five observer and two self-rated scales. Percent recovery rates were higher for amitriptyline than placebo on two measures. In patients who completed 4 weeks (n = 40), better outcome with amitriptyline was noted on the Hamilton depression scale only. In the group completing 8 weeks of treatment (n = 33), the drug was superior to placebo on Hamilton depression, Hamilton anxiety, Clinical Global Impression severity, and Impact of Event scales. There was no evidence for drug effects on the structured interview for posttraumatic stress disorder. Drug-placebo differences were greater in the presence of comorbidity in general, although recovery rates were uniformly low in the presence of major depression, panic disorder, and alcoholism. At the end of treatment, 64% of the amitriptyline and 72% of the placebo samples still met diagnostic criteria for posttraumatic stress disorder.

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Published In

Arch Gen Psychiatry

DOI

ISSN

0003-990X

Publication Date

March 1990

Volume

47

Issue

3

Start / End Page

259 / 266

Location

United States

Related Subject Headings

  • Warfare
  • Stress Disorders, Post-Traumatic
  • Psychiatry
  • Psychiatric Status Rating Scales
  • Placebos
  • Panic
  • Outcome and Process Assessment, Health Care
  • Mental Disorders
  • Humans
  • Hospitalization
 

Citation

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Chicago
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Davidson, J., Kudler, H., Smith, R., Mahorney, S. L., Lipper, S., Hammett, E., … Cavenar, J. O. (1990). Treatment of posttraumatic stress disorder with amitriptyline and placebo. Arch Gen Psychiatry, 47(3), 259–266. https://doi.org/10.1001/archpsyc.1990.01810150059010
Davidson, J., H. Kudler, R. Smith, S. L. Mahorney, S. Lipper, E. Hammett, W. B. Saunders, and J. O. Cavenar. “Treatment of posttraumatic stress disorder with amitriptyline and placebo.Arch Gen Psychiatry 47, no. 3 (March 1990): 259–66. https://doi.org/10.1001/archpsyc.1990.01810150059010.
Davidson J, Kudler H, Smith R, Mahorney SL, Lipper S, Hammett E, et al. Treatment of posttraumatic stress disorder with amitriptyline and placebo. Arch Gen Psychiatry. 1990 Mar;47(3):259–66.
Davidson, J., et al. “Treatment of posttraumatic stress disorder with amitriptyline and placebo.Arch Gen Psychiatry, vol. 47, no. 3, Mar. 1990, pp. 259–66. Pubmed, doi:10.1001/archpsyc.1990.01810150059010.
Davidson J, Kudler H, Smith R, Mahorney SL, Lipper S, Hammett E, Saunders WB, Cavenar JO. Treatment of posttraumatic stress disorder with amitriptyline and placebo. Arch Gen Psychiatry. 1990 Mar;47(3):259–266.

Published In

Arch Gen Psychiatry

DOI

ISSN

0003-990X

Publication Date

March 1990

Volume

47

Issue

3

Start / End Page

259 / 266

Location

United States

Related Subject Headings

  • Warfare
  • Stress Disorders, Post-Traumatic
  • Psychiatry
  • Psychiatric Status Rating Scales
  • Placebos
  • Panic
  • Outcome and Process Assessment, Health Care
  • Mental Disorders
  • Humans
  • Hospitalization