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The corticotropin-releasing hormone test in patients with posttraumatic stress disorder.

Publication ,  Journal Article
Smith, MA; Davidson, J; Ritchie, JC; Kudler, H; Lipper, S; Chappell, P; Nemeroff, CB
Published in: Biol Psychiatry
August 1989

To evaluate the hypothalamic-pituitary-adrenal (HPA) axis in patients with posttraumatic stress disorder (PTSD), we measured adrenocorticotropin hormone (ACTH) and cortisol responses following administration of corticotropin-releasing hormone (CRH) in 8 combat veterans with chronic PTSD. The PTSD patients had a significantly lower ACTH response to CRH compared to a control group of normal volunteers. Blunted ACTH responses occurred in patients with PTSD alone, as well as those PTSD patients who also had major depression. The cortisol response, although reduced, was not significantly different from normal. The blunted ACTH response to CRH in PTSD patients is similar to that seen in other psychiatric disorders, such as depression, panic disorder, and anorexia nervosa.

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Published In

Biol Psychiatry

DOI

ISSN

0006-3223

Publication Date

August 1989

Volume

26

Issue

4

Start / End Page

349 / 355

Location

United States

Related Subject Headings

  • Stress Disorders, Post-Traumatic
  • Psychiatry
  • Male
  • Infusions, Intravenous
  • Hydrocortisone
  • Humans
  • Corticotropin-Releasing Hormone
  • Adult
  • Adrenocorticotropic Hormone
  • 52 Psychology
 

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Smith, M. A., Davidson, J., Ritchie, J. C., Kudler, H., Lipper, S., Chappell, P., & Nemeroff, C. B. (1989). The corticotropin-releasing hormone test in patients with posttraumatic stress disorder. Biol Psychiatry, 26(4), 349–355. https://doi.org/10.1016/0006-3223(89)90050-4
Smith, M. A., J. Davidson, J. C. Ritchie, H. Kudler, S. Lipper, P. Chappell, and C. B. Nemeroff. “The corticotropin-releasing hormone test in patients with posttraumatic stress disorder.Biol Psychiatry 26, no. 4 (August 1989): 349–55. https://doi.org/10.1016/0006-3223(89)90050-4.
Smith MA, Davidson J, Ritchie JC, Kudler H, Lipper S, Chappell P, et al. The corticotropin-releasing hormone test in patients with posttraumatic stress disorder. Biol Psychiatry. 1989 Aug;26(4):349–55.
Smith, M. A., et al. “The corticotropin-releasing hormone test in patients with posttraumatic stress disorder.Biol Psychiatry, vol. 26, no. 4, Aug. 1989, pp. 349–55. Pubmed, doi:10.1016/0006-3223(89)90050-4.
Smith MA, Davidson J, Ritchie JC, Kudler H, Lipper S, Chappell P, Nemeroff CB. The corticotropin-releasing hormone test in patients with posttraumatic stress disorder. Biol Psychiatry. 1989 Aug;26(4):349–355.
Journal cover image

Published In

Biol Psychiatry

DOI

ISSN

0006-3223

Publication Date

August 1989

Volume

26

Issue

4

Start / End Page

349 / 355

Location

United States

Related Subject Headings

  • Stress Disorders, Post-Traumatic
  • Psychiatry
  • Male
  • Infusions, Intravenous
  • Hydrocortisone
  • Humans
  • Corticotropin-Releasing Hormone
  • Adult
  • Adrenocorticotropic Hormone
  • 52 Psychology