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Relationship of race/ethnicity and survival after single umbilical cord blood transplantation for adults and children with leukemia and myelodysplastic syndromes.

Publication ,  Journal Article
Ballen, KK; Klein, JP; Pedersen, TL; Bhatla, D; Duerst, R; Kurtzberg, J; Lazarus, HM; LeMaistre, CF; McCarthy, P; Mehta, P; Palmer, J; Lee, SJ ...
Published in: Biol Blood Marrow Transplant
June 2012

The relationship of race/ethnicity with outcomes of umbilical cord blood transplantation (UCBT) is not well known. We analyzed the association between race/ethnicity and outcomes of unrelated single UCBT for leukemia and myelodysplastic syndromes. Our retrospective cohort study consisted of 885 adults and children (612 whites, 145 blacks, and 128 Hispanics) who received unrelated single UCBT for leukemia and myelodysplastic syndromes between 1995 and 2006 and were reported to the Center for International Blood and Marrow Transplant Research. A 5-6/6 HLA-matched unit with a total nucleated cell count infused of ≥2.5 × 10(7)/kg was given to 40% white and 42% Hispanic, but only 21% black patients. Overall survival at 2 years was 44% for whites, 34% for blacks, and 46% for Hispanics (P = .008). In multivariate analysis adjusting for patient, disease, and treatment factors (including HLA match and cell dose), blacks had inferior overall survival (relative risk of death, 1.31; P = .02), whereas overall survival of Hispanics was similar (relative risk, 1.03; P = .81) to that of whites. For all patients, younger age, early-stage disease, use of units with higher cell dose, and performance status ≥80 were independent predictors of improved survival. Black patients and white patients infused with well-matched cords had comparable survival; similarly, black and white patients receiving units with adequate cell dose had similar survival. These results suggest that blacks have inferior survival to whites after single UCBT, but outcomes are improved when units with a higher cell dose are used.

Duke Scholars

Published In

Biol Blood Marrow Transplant

DOI

EISSN

1523-6536

Publication Date

June 2012

Volume

18

Issue

6

Start / End Page

903 / 912

Location

United States

Related Subject Headings

  • White People
  • United States
  • Treatment Outcome
  • Retrospective Studies
  • Myelodysplastic Syndromes
  • Middle Aged
  • Male
  • Leukemia
  • Infant
  • Immunology
 

Citation

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Ballen, K. K., Klein, J. P., Pedersen, T. L., Bhatla, D., Duerst, R., Kurtzberg, J., … Majhail, N. S. (2012). Relationship of race/ethnicity and survival after single umbilical cord blood transplantation for adults and children with leukemia and myelodysplastic syndromes. Biol Blood Marrow Transplant, 18(6), 903–912. https://doi.org/10.1016/j.bbmt.2011.10.040
Ballen, Karen K., John P. Klein, Tanya L. Pedersen, Deepika Bhatla, Reggie Duerst, Joanne Kurtzberg, Hillard M. Lazarus, et al. “Relationship of race/ethnicity and survival after single umbilical cord blood transplantation for adults and children with leukemia and myelodysplastic syndromes.Biol Blood Marrow Transplant 18, no. 6 (June 2012): 903–12. https://doi.org/10.1016/j.bbmt.2011.10.040.
Ballen KK, Klein JP, Pedersen TL, Bhatla D, Duerst R, Kurtzberg J, et al. Relationship of race/ethnicity and survival after single umbilical cord blood transplantation for adults and children with leukemia and myelodysplastic syndromes. Biol Blood Marrow Transplant. 2012 Jun;18(6):903–12.
Ballen, Karen K., et al. “Relationship of race/ethnicity and survival after single umbilical cord blood transplantation for adults and children with leukemia and myelodysplastic syndromes.Biol Blood Marrow Transplant, vol. 18, no. 6, June 2012, pp. 903–12. Pubmed, doi:10.1016/j.bbmt.2011.10.040.
Ballen KK, Klein JP, Pedersen TL, Bhatla D, Duerst R, Kurtzberg J, Lazarus HM, LeMaistre CF, McCarthy P, Mehta P, Palmer J, Setterholm M, Wingard JR, Joffe S, Parsons SK, Switzer GE, Lee SJ, Rizzo JD, Majhail NS. Relationship of race/ethnicity and survival after single umbilical cord blood transplantation for adults and children with leukemia and myelodysplastic syndromes. Biol Blood Marrow Transplant. 2012 Jun;18(6):903–912.
Journal cover image

Published In

Biol Blood Marrow Transplant

DOI

EISSN

1523-6536

Publication Date

June 2012

Volume

18

Issue

6

Start / End Page

903 / 912

Location

United States

Related Subject Headings

  • White People
  • United States
  • Treatment Outcome
  • Retrospective Studies
  • Myelodysplastic Syndromes
  • Middle Aged
  • Male
  • Leukemia
  • Infant
  • Immunology