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Hematopoietic cell transplantation with cord blood for cure of HIV infections.

Publication ,  Journal Article
Petz, LD; Redei, I; Bryson, Y; Regan, D; Kurtzberg, J; Shpall, E; Gutman, J; Querol, S; Clark, P; Tonai, R; Santos, S; Bravo, A; Spellman, S ...
Published in: Biol Blood Marrow Transplant
March 2013

Hematopoietic cell transplantation (HCT) using CCR5-Δ32/Δ32 stem cells from an adult donor has resulted in the only known cure of human immunodeficiency virus (HIV) infection. However, it is not feasible to repeat this procedure except rarely because of the low incidence of the CCR5-Δ32 allele, the availability of only a small number of potential donors for most patients, and the need for a very close human leukocyte antigen (HLA) match between adult donors and recipients. In contrast, cord blood (CB) transplantations require significantly less stringent HLA matching. Therefore, our hypothesis is that cure of HIV infections by HCT can be accomplished much more readily using umbilical CB stem cells obtained from a modestly sized inventory of cryopreserved CCR5-Δ32/Δ32 CB units. To test this hypothesis, we developed a screening program for CB units and are developing an inventory of CCR5-Δ32/Δ32 cryopreserved units available for HCT. Three hundred such units are projected to provide for white pediatric patients a 73.6% probability of finding an adequately HLA matched unit with a cell dose of ≥2.5 × 10(7) total nucleated cells (TNCs)/kg and a 27.9% probability for white adults. With a cell dose of ≥1 × 10(7) TNCs/kg, the corresponding projected probabilities are 85.6% and 82.1%. The projected probabilities are lower for ethnic minorities. Impetus for using CB HCT was provided by a transplantation of an adult with acute myelogenous leukemia who was not HIV infected. The HCT was performed with a CCR5-Δ32/Δ32 CB unit, and posttransplantation in vitro studies indicated that the patient's peripheral blood mononuclear cells were resistant to HIV infection.

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Published In

Biol Blood Marrow Transplant

DOI

EISSN

1523-6536

Publication Date

March 2013

Volume

19

Issue

3

Start / End Page

393 / 397

Location

United States

Related Subject Headings

  • White People
  • Unrelated Donors
  • Transplantation Chimera
  • Sequence Deletion
  • Receptors, CCR5
  • Probability
  • Leukocytes, Mononuclear
  • Leukemia, Myeloid, Acute
  • Immunology
  • Humans
 

Citation

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Petz, L. D., Redei, I., Bryson, Y., Regan, D., Kurtzberg, J., Shpall, E., … Chow, R. (2013). Hematopoietic cell transplantation with cord blood for cure of HIV infections. Biol Blood Marrow Transplant, 19(3), 393–397. https://doi.org/10.1016/j.bbmt.2012.10.017
Petz, Lawrence D., Istvan Redei, Yvonne Bryson, Donna Regan, Joanne Kurtzberg, Elizabeth Shpall, Jonathan Gutman, et al. “Hematopoietic cell transplantation with cord blood for cure of HIV infections.Biol Blood Marrow Transplant 19, no. 3 (March 2013): 393–97. https://doi.org/10.1016/j.bbmt.2012.10.017.
Petz LD, Redei I, Bryson Y, Regan D, Kurtzberg J, Shpall E, et al. Hematopoietic cell transplantation with cord blood for cure of HIV infections. Biol Blood Marrow Transplant. 2013 Mar;19(3):393–7.
Petz, Lawrence D., et al. “Hematopoietic cell transplantation with cord blood for cure of HIV infections.Biol Blood Marrow Transplant, vol. 19, no. 3, Mar. 2013, pp. 393–97. Pubmed, doi:10.1016/j.bbmt.2012.10.017.
Petz LD, Redei I, Bryson Y, Regan D, Kurtzberg J, Shpall E, Gutman J, Querol S, Clark P, Tonai R, Santos S, Bravo A, Spellman S, Gragert L, Rossi J, Li S, Li H, Senitzer D, Zaia J, Rosenthal J, Forman S, Chow R. Hematopoietic cell transplantation with cord blood for cure of HIV infections. Biol Blood Marrow Transplant. 2013 Mar;19(3):393–397.
Journal cover image

Published In

Biol Blood Marrow Transplant

DOI

EISSN

1523-6536

Publication Date

March 2013

Volume

19

Issue

3

Start / End Page

393 / 397

Location

United States

Related Subject Headings

  • White People
  • Unrelated Donors
  • Transplantation Chimera
  • Sequence Deletion
  • Receptors, CCR5
  • Probability
  • Leukocytes, Mononuclear
  • Leukemia, Myeloid, Acute
  • Immunology
  • Humans