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The impact of induction chemotherapy and the associated tumor response on subsequent radiation-related changes in lung function and tumor response.

Publication ,  Journal Article
Mao, J; Kocak, Z; Zhou, S; Garst, J; Evans, ES; Zhang, J; Larrier, NA; Hollis, DR; Folz, RJ; Marks, LB
Published in: Int J Radiat Oncol Biol Phys
April 1, 2007

PURPOSE: To assess the impact of induction chemotherapy, and associated tumor shrinkage, on the subsequent radiation-related changes in pulmonary function and tumor response. METHODS AND MATERIALS: As part of a prospective institutional review board-approved study, 91 evaluable patients treated definitively with thoracic radiation therapy (RT) for unresectable lung cancer were analyzed. The rates of RT-associated pulmonary toxicity and tumor response were compared in the patients with and without pre-RT chemotherapy. In the patients receiving induction chemotherapy, the rates of RT-associated pulmonary toxicity and tumor response were compared in the patients with and without a response (modified Response Evaluation Criteria in Solid Tumor criteria) to the pre-RT chemotherapy. Comparisons of the rates of improvements in pulmonary function tests (PFTs) post-RT, dyspnea requiring steroids, and percent declines in PFTs post-RT were compared in patient subgroups using Fisher's exact test, analysis of variance, and linear or logistic regression. RESULTS: The use of pre-RT chemotherapy appears to increase the rate of radiation-induced pneumonitis (p = 0.009-0.07), but has no consistent impact on changes in PFTs. The degree of induction chemotherapy-associated tumor shrinkage is not associated with the rate of subsequent RT-associated pulmonary toxicity. The degree of tumor response to chemotherapy is not related to the degree of tumor response to RT. CONCLUSIONS: Additional study is needed to better clarify the impact of chemotherapy on radiation-associated disfunction.

Duke Scholars

Published In

Int J Radiat Oncol Biol Phys

DOI

ISSN

0360-3016

Publication Date

April 1, 2007

Volume

67

Issue

5

Start / End Page

1360 / 1369

Location

United States

Related Subject Headings

  • Vital Capacity
  • Remission Induction
  • Radiation Pneumonitis
  • Prospective Studies
  • Oncology & Carcinogenesis
  • Multivariate Analysis
  • Middle Aged
  • Male
  • Lung Neoplasms
  • Lung
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Mao, J., Kocak, Z., Zhou, S., Garst, J., Evans, E. S., Zhang, J., … Marks, L. B. (2007). The impact of induction chemotherapy and the associated tumor response on subsequent radiation-related changes in lung function and tumor response. Int J Radiat Oncol Biol Phys, 67(5), 1360–1369. https://doi.org/10.1016/j.ijrobp.2006.11.003
Mao, Jingfang, Zafer Kocak, Sumin Zhou, Jennifer Garst, Elizabeth S. Evans, Junan Zhang, Nicole A. Larrier, Donna R. Hollis, Rodney J. Folz, and Lawrence B. Marks. “The impact of induction chemotherapy and the associated tumor response on subsequent radiation-related changes in lung function and tumor response.Int J Radiat Oncol Biol Phys 67, no. 5 (April 1, 2007): 1360–69. https://doi.org/10.1016/j.ijrobp.2006.11.003.
Mao J, Kocak Z, Zhou S, Garst J, Evans ES, Zhang J, et al. The impact of induction chemotherapy and the associated tumor response on subsequent radiation-related changes in lung function and tumor response. Int J Radiat Oncol Biol Phys. 2007 Apr 1;67(5):1360–9.
Mao, Jingfang, et al. “The impact of induction chemotherapy and the associated tumor response on subsequent radiation-related changes in lung function and tumor response.Int J Radiat Oncol Biol Phys, vol. 67, no. 5, Apr. 2007, pp. 1360–69. Pubmed, doi:10.1016/j.ijrobp.2006.11.003.
Mao J, Kocak Z, Zhou S, Garst J, Evans ES, Zhang J, Larrier NA, Hollis DR, Folz RJ, Marks LB. The impact of induction chemotherapy and the associated tumor response on subsequent radiation-related changes in lung function and tumor response. Int J Radiat Oncol Biol Phys. 2007 Apr 1;67(5):1360–1369.
Journal cover image

Published In

Int J Radiat Oncol Biol Phys

DOI

ISSN

0360-3016

Publication Date

April 1, 2007

Volume

67

Issue

5

Start / End Page

1360 / 1369

Location

United States

Related Subject Headings

  • Vital Capacity
  • Remission Induction
  • Radiation Pneumonitis
  • Prospective Studies
  • Oncology & Carcinogenesis
  • Multivariate Analysis
  • Middle Aged
  • Male
  • Lung Neoplasms
  • Lung