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Design of the Trial to Assess Chelation Therapy (TACT).

Publication ,  Journal Article
Lamas, GA; Goertz, C; Boineau, R; Mark, DB; Rozema, T; Nahin, RL; Drisko, JA; Lee, KL
Published in: Am Heart J
January 2012

TACT is an National Institutes of Health-sponsored, randomized, double-blind, placebo-controlled, 2 × 2 factorial clinical trial testing the benefits and risks of 40 infusions of a multicomponent disodium EDTA chelation solution compared with placebo and of an oral, high-dose multivitamin and mineral supplement. TACT has randomized and will follow up 1,708 patients for an average of approximately 4 years. The primary end point is a composite of all-cause mortality, myocardial infarction, stroke, coronary revascularization, and hospitalization for angina. A 900-patient substudy will examine quality-of-life outcomes. The trial is designed to have >85% power to detect a 25% relative reduction in the primary end point for each treatment factor. Enrollment began in September 2003 and was completed in October 2010.

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Published In

Am Heart J

DOI

EISSN

1097-6744

Publication Date

January 2012

Volume

163

Issue

1

Start / End Page

7 / 12

Location

United States

Related Subject Headings

  • Vitamins
  • Treatment Outcome
  • Research Design
  • Minerals
  • Middle Aged
  • Male
  • Humans
  • Female
  • Edetic Acid
  • Double-Blind Method
 

Citation

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MLA
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Lamas, G. A., Goertz, C., Boineau, R., Mark, D. B., Rozema, T., Nahin, R. L., … Lee, K. L. (2012). Design of the Trial to Assess Chelation Therapy (TACT). Am Heart J, 163(1), 7–12. https://doi.org/10.1016/j.ahj.2011.10.002
Lamas, Gervasio A., Christine Goertz, Robin Boineau, Daniel B. Mark, Theodore Rozema, Richard L. Nahin, Jeanne A. Drisko, and Kerry L. Lee. “Design of the Trial to Assess Chelation Therapy (TACT).Am Heart J 163, no. 1 (January 2012): 7–12. https://doi.org/10.1016/j.ahj.2011.10.002.
Lamas GA, Goertz C, Boineau R, Mark DB, Rozema T, Nahin RL, et al. Design of the Trial to Assess Chelation Therapy (TACT). Am Heart J. 2012 Jan;163(1):7–12.
Lamas, Gervasio A., et al. “Design of the Trial to Assess Chelation Therapy (TACT).Am Heart J, vol. 163, no. 1, Jan. 2012, pp. 7–12. Pubmed, doi:10.1016/j.ahj.2011.10.002.
Lamas GA, Goertz C, Boineau R, Mark DB, Rozema T, Nahin RL, Drisko JA, Lee KL. Design of the Trial to Assess Chelation Therapy (TACT). Am Heart J. 2012 Jan;163(1):7–12.
Journal cover image

Published In

Am Heart J

DOI

EISSN

1097-6744

Publication Date

January 2012

Volume

163

Issue

1

Start / End Page

7 / 12

Location

United States

Related Subject Headings

  • Vitamins
  • Treatment Outcome
  • Research Design
  • Minerals
  • Middle Aged
  • Male
  • Humans
  • Female
  • Edetic Acid
  • Double-Blind Method