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Systematic review of 99mTc human serum albumin and 99mTc sulfur colloid studies of sentinel lymph node biopsy of cutaneous melanoma of the head and neck

Publication ,  Conference
De Rosa, N; Lyman, GH; Silbermins, D; Valsecchi, ME; Wong, S; Pruitt, SK; Lee, WT
Published in: Laryngoscope
July 11, 2011

Introduction: Sentinel lymph node biopsy (SLNB) of head and neck melanoma presents a technical challenge due to the multiplicity of basins and variable lymph node drainage. Radiotracer size and particulate nature determines speed of lymphatic drainage into nodal basins, as well as nodal uptake and retention. Human serum albumin (HSA) and sulfur colloid (SC) are commonly used radiotracers with divergent chemical characteristics. Results: Eligibility criteria were met for 26 studies (n=2257), 7 prospective and 19 retrospective. Of these, 8 studies (n=422) used HSA and 18 studies (n=1835) used SC. The identification rates of sentinel nodes for HSA and SC were 91.7% and 97.5%, respectively. The false negative rate was 12.5% and 12.2% in HSA and SC, respectively. The median post-test probability negative for nodal recurrence and for total recurrence was 3.9% and 12.6%, and 2.1% and 11.6%, respectively, for HSA and SC. Conclusion Although HSA and SC have different intrinsic chemical properties, both are efficacious for use in SLNB of cutaneous melanoma of the head and neck.

Duke Scholars

Published In

Laryngoscope

DOI

EISSN

1531-4995

ISSN

0023-852X

Publication Date

July 11, 2011

Volume

121

Issue

SUPPL. 4

Related Subject Headings

  • Otorhinolaryngology
  • 3202 Clinical sciences
  • 1103 Clinical Sciences
 

Citation

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De Rosa, N., Lyman, G. H., Silbermins, D., Valsecchi, M. E., Wong, S., Pruitt, S. K., & Lee, W. T. (2011). Systematic review of 99mTc human serum albumin and 99mTc sulfur colloid studies of sentinel lymph node biopsy of cutaneous melanoma of the head and neck. In Laryngoscope (Vol. 121). https://doi.org/10.1002/lary.21983
De Rosa, N., G. H. Lyman, D. Silbermins, M. E. Valsecchi, S. Wong, S. K. Pruitt, and W. T. Lee. “Systematic review of 99mTc human serum albumin and 99mTc sulfur colloid studies of sentinel lymph node biopsy of cutaneous melanoma of the head and neck.” In Laryngoscope, Vol. 121, 2011. https://doi.org/10.1002/lary.21983.
De Rosa, N., et al. “Systematic review of 99mTc human serum albumin and 99mTc sulfur colloid studies of sentinel lymph node biopsy of cutaneous melanoma of the head and neck.” Laryngoscope, vol. 121, no. SUPPL. 4, 2011. Scopus, doi:10.1002/lary.21983.
Journal cover image

Published In

Laryngoscope

DOI

EISSN

1531-4995

ISSN

0023-852X

Publication Date

July 11, 2011

Volume

121

Issue

SUPPL. 4

Related Subject Headings

  • Otorhinolaryngology
  • 3202 Clinical sciences
  • 1103 Clinical Sciences