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Gene transfer strategies for augmenting cardiac function.

Publication ,  Journal Article
Peppel, K; Koch, WJ; Lefkowitz, RJ
Published in: Trends Cardiovasc Med
July 1997

Recent transgenic as well as gene-targeted animal models have greatly increased our understanding of the molecular mechanisms of normal and compromised heart function. These studies have raised the possibility of using somatic gene transfer as a means for improving cardiac function. DNA transfer to a significant portion of the myocardium has thus far been difficult to accomplish. This review describes current efforts to achieve myocardial gene transfer in several model systems, with particular emphasis placed on adenovirus-mediated gene delivery, its possibilities, and current limitations. (Trend Cardiovasc Med 1997;7:145-150). © 1997, Elsevier Science Inc.

Duke Scholars

Published In

Trends Cardiovasc Med

DOI

ISSN

1050-1738

Publication Date

July 1997

Volume

7

Issue

5

Start / End Page

145 / 150

Location

United States

Related Subject Headings

  • Cardiovascular System & Hematology
  • 3201 Cardiovascular medicine and haematology
  • 1102 Cardiorespiratory Medicine and Haematology
 

Citation

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Peppel, K., Koch, W. J., & Lefkowitz, R. J. (1997). Gene transfer strategies for augmenting cardiac function. Trends Cardiovasc Med, 7(5), 145–150. https://doi.org/10.1016/S1050-1738(97)00028-5
Peppel, K., W. J. Koch, and R. J. Lefkowitz. “Gene transfer strategies for augmenting cardiac function.Trends Cardiovasc Med 7, no. 5 (July 1997): 145–50. https://doi.org/10.1016/S1050-1738(97)00028-5.
Peppel K, Koch WJ, Lefkowitz RJ. Gene transfer strategies for augmenting cardiac function. Trends Cardiovasc Med. 1997 Jul;7(5):145–50.
Peppel, K., et al. “Gene transfer strategies for augmenting cardiac function.Trends Cardiovasc Med, vol. 7, no. 5, July 1997, pp. 145–50. Pubmed, doi:10.1016/S1050-1738(97)00028-5.
Peppel K, Koch WJ, Lefkowitz RJ. Gene transfer strategies for augmenting cardiac function. Trends Cardiovasc Med. 1997 Jul;7(5):145–150.
Journal cover image

Published In

Trends Cardiovasc Med

DOI

ISSN

1050-1738

Publication Date

July 1997

Volume

7

Issue

5

Start / End Page

145 / 150

Location

United States

Related Subject Headings

  • Cardiovascular System & Hematology
  • 3201 Cardiovascular medicine and haematology
  • 1102 Cardiorespiratory Medicine and Haematology