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Mercury-induced cognitive impairment in metallothionein-1/2 null mice.

Publication ,  Journal Article
Eddins, D; Petro, A; Pollard, N; Freedman, JH; Levin, ED
Published in: Neurotoxicol Teratol
2008

Metallothioneins are central for the metabolism and detoxification of transition metals. Exposure to mercury during early neurodevelopment is associated with neurocognitive impairment. Given the importance of metallothioneins in mercury detoxification, metallothioneins may be a protective factor against mercury-induced neurocognitive impairment. Deletion of the murine metallothionein-1 and metallothionein-2 genes causes choice accuracy impairments in the 8-arm radial maze. We hypothesize that deletions of metallothioneins genes will make metallothionein-null mice more vulnerable to mercury-induced cognitive impairment. We tested this hypothesis by exposing MT1/MT2-null and wild-type mice to developmental mercury (HgCl(2)) and evaluated the resultant effects on cognitive performance on the 8-arm radial maze. During the early phase of learning metallothionein-null mice were more susceptible to mercury-induced impairment compared to wildtype mice. Neurochemical analysis of the frontal cortex revealed that serotonin levels were higher in metallothionein-null mice compared to wild-type mice. This effect was independent of mercury exposure. However, dopamine levels in mercury-exposed metallothionein-null mice were lower compared to mercury-exposed wild-type mice. This work shows that deleting metallothioneins increase the vulnerability to developmental mercury-induced neurocognitive impairment. Metallothionein effects on monoamine transmitters may be related to this cognitive effect.

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Published In

Neurotoxicol Teratol

DOI

ISSN

0892-0362

Publication Date

2008

Volume

30

Issue

2

Start / End Page

88 / 95

Location

United States

Related Subject Headings

  • Toxicology
  • Serotonin
  • Mice, Knockout
  • Mice
  • Metallothionein
  • Mercury Poisoning, Nervous System
  • Maze Learning
  • Genotype
  • Cognition Disorders
  • Brain Chemistry
 

Citation

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ICMJE
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Eddins, D., Petro, A., Pollard, N., Freedman, J. H., & Levin, E. D. (2008). Mercury-induced cognitive impairment in metallothionein-1/2 null mice. Neurotoxicol Teratol, 30(2), 88–95. https://doi.org/10.1016/j.ntt.2007.12.005
Eddins, Donnie, Ann Petro, Ninitia Pollard, Jonathan H. Freedman, and Edward D. Levin. “Mercury-induced cognitive impairment in metallothionein-1/2 null mice.Neurotoxicol Teratol 30, no. 2 (2008): 88–95. https://doi.org/10.1016/j.ntt.2007.12.005.
Eddins D, Petro A, Pollard N, Freedman JH, Levin ED. Mercury-induced cognitive impairment in metallothionein-1/2 null mice. Neurotoxicol Teratol. 2008;30(2):88–95.
Eddins, Donnie, et al. “Mercury-induced cognitive impairment in metallothionein-1/2 null mice.Neurotoxicol Teratol, vol. 30, no. 2, 2008, pp. 88–95. Pubmed, doi:10.1016/j.ntt.2007.12.005.
Eddins D, Petro A, Pollard N, Freedman JH, Levin ED. Mercury-induced cognitive impairment in metallothionein-1/2 null mice. Neurotoxicol Teratol. 2008;30(2):88–95.
Journal cover image

Published In

Neurotoxicol Teratol

DOI

ISSN

0892-0362

Publication Date

2008

Volume

30

Issue

2

Start / End Page

88 / 95

Location

United States

Related Subject Headings

  • Toxicology
  • Serotonin
  • Mice, Knockout
  • Mice
  • Metallothionein
  • Mercury Poisoning, Nervous System
  • Maze Learning
  • Genotype
  • Cognition Disorders
  • Brain Chemistry